Antimycobacterial agents

Question 1

mycobacterium replicate _______, lay ______, have a waxy outer cell wall

Answer 1

slowly
dormant (highly resistant!)

Question 2

Isoniazid prevents the synthesis of _______ in the cell wall

Answer 2

mycolic acids

Question 3

isoniazid is only used for latent ______

Answer 3

TB

Question 4

notorious AR for isoniazid is ______ _______ and ______ ______

Answer 4

peripheral neuropathy

hepatotoxicity

Question 5

rifampin is a drug of choice for ACTIVE __________. Colors secretions _____

Answer 5

mycobacterium tB

red

Question 6

rifampin is a protein synthesis inhibitor for____________, preventing transcription of DNA to bacterial mRNA

Answer 6

RNA polymerase

Question 7

major problem with rifampin/rifabutin is that they _________ cytochrome p450

Answer 7

induce (problem for drug interactions)

Question 8

hepatoxicity and Hyperuricemia are AR of ______

Answer 8

pyrazinamide

Question 9

______ has the broadest scope with mycobacterial (first line active TB drug), but it can cause ______

Answer 9

ethambutol

optic neuritis

Question 10

peptidoglycan layer that is in the cell wall is not accessible by _____ _____. Waxy outer layer has _________ that prevent ________ penetration

Answer 10

beta lactams
mycolic acids
antibiotic