Immune Reactions to Drugs Flashcards

1
Q

most common hypersensitivies are type ___ (IgE) and ___ (delayed, helper T)

A

I and 4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

type 3 hypersensitivity is mediated by ____ - ____ complexes.

A

antigen-antibody complexes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

allergen cross-links IgE o ____ ____ surface in type I

A

mast cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

“wheal and flare”: edema, erythema, and itching occur in type ___

A

I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

late phase of type I occurs ___ hours after exposure

A

6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

non-allergic persons respond to allergens by producing ____, which doesn’t cause the release of mediators from mast cells, whereas allergic persons release _____

A

IgG

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

severe bronchospasm and hypotension occur in systemic _________

A

anaphylactic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

angioedema is swelling of deep dermis, subcutaneous, or submucosal tissue to vascular leakage. Occurs via ______

A

bradykinin (hereditary) or histamine (allergicY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

drug hypersensitivity is usually from a ________ ______, not the intact drug itself

A

metabolic product

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

small amounts of antigen over 15 minute intervals, leads to antigen-IgE complexes rather than __________ on mast cells

A

cross-linked IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Chronic desensitization occurs with ______ administration, promoting production of IgA and IgG blocking antibodies, which prevents the antigen from reaching ______ _____

A

mast cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

IgG or IgM are directed at antigens of the cell brane and activate _______. This is type ___

A

complement

type II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

hemolytic anemia, ABO transfusion reactions are clinical manifestations of type ___

A

II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

IgG triggers the complement system in type _____

A

II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

soluble antigen-antibody complexes that deposit on basement membranes of tissues and vessels occurs in type ____

A

III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

in type III, the complexes form so rapidly that they overwhelm the system. the _____ system is activated and inflammation occurs

A

complement

17
Q

serum sickness is an example of type _____, which is systemic inflammation that occurs from the immune complexes

A

III

18
Q

acute poststreptococall glomerulonephritis is a typical _____ _____ disease, following group A strep. Strep antigen-antibody complexes are deposited on the glomeruli, fix _____ and attract ______

A

immune complex
complement
neutrophils

19
Q

deposits of immune complexes on synovial membranes causes _______ ______

A

rheumatoid arthritis

20
Q

type IV is a function of _______, not antibody

A

T lymphoctes

21
Q

type IV is ______, occurring 2-3 days after exposure

A

delayed

22
Q

tuberculin, contact dermatitis occur in type ____

A

IV