Immune Reactions to Drugs Flashcards
most common hypersensitivies are type ___ (IgE) and ___ (delayed, helper T)
I and 4
type 3 hypersensitivity is mediated by ____ - ____ complexes.
antigen-antibody complexes
allergen cross-links IgE o ____ ____ surface in type I
mast cell
“wheal and flare”: edema, erythema, and itching occur in type ___
I
late phase of type I occurs ___ hours after exposure
6
non-allergic persons respond to allergens by producing ____, which doesn’t cause the release of mediators from mast cells, whereas allergic persons release _____
IgG
IgE
severe bronchospasm and hypotension occur in systemic _________
anaphylactic
angioedema is swelling of deep dermis, subcutaneous, or submucosal tissue to vascular leakage. Occurs via ______
bradykinin (hereditary) or histamine (allergicY
drug hypersensitivity is usually from a ________ ______, not the intact drug itself
metabolic product
small amounts of antigen over 15 minute intervals, leads to antigen-IgE complexes rather than __________ on mast cells
cross-linked IgE
Chronic desensitization occurs with ______ administration, promoting production of IgA and IgG blocking antibodies, which prevents the antigen from reaching ______ _____
mast cells
IgG or IgM are directed at antigens of the cell brane and activate _______. This is type ___
complement
type II
hemolytic anemia, ABO transfusion reactions are clinical manifestations of type ___
II
IgG triggers the complement system in type _____
II
soluble antigen-antibody complexes that deposit on basement membranes of tissues and vessels occurs in type ____
III
in type III, the complexes form so rapidly that they overwhelm the system. the _____ system is activated and inflammation occurs
complement
serum sickness is an example of type _____, which is systemic inflammation that occurs from the immune complexes
III
acute poststreptococall glomerulonephritis is a typical _____ _____ disease, following group A strep. Strep antigen-antibody complexes are deposited on the glomeruli, fix _____ and attract ______
immune complex
complement
neutrophils
deposits of immune complexes on synovial membranes causes _______ ______
rheumatoid arthritis
type IV is a function of _______, not antibody
T lymphoctes
type IV is ______, occurring 2-3 days after exposure
delayed
tuberculin, contact dermatitis occur in type ____
IV
