anti-fungals

Question 1

the polyenes are a class of antimycotics and they disrupt the cell wall of ________ by binding to _______

Answer 1

fungi

ergosterol

Question 2

amphotericin and nystatin are ________

Answer 2

polyenes

Question 3

major problem of amphotericin is ______

Answer 3

toxicity

Question 4

fluconazole is an ______ that inhibits a ____ enzyme, preventing the production of ______

Answer 4

antifungal
cytochrome p450
ergosterol

Question 5

Fluconazole is active against _______, cryptococcus (meningitis) coccidioidies

Answer 5

candida albicans

Question 6

because the -azoles inhibit p450 enzymes, they have multiple ___________

Answer 6

drug interactions

Question 7

fluconazole is well tolerated - ADRs include _____ steroid production, hepatotoxicity, or _____ of the QT interval

Answer 7

decreased

prolongation

Question 8

parasites can be separated into ______ and multicellular ______

Answer 8

unicellular protozoa

multicellular helminthes

Question 9

________ is used for intestinal helminth infection

Answer 9

mebedazole (vermox)

Question 10

mebendazole disrupts the grown and division of _____

Answer 10

worms, mostly intestinal worms

Question 11

chloroquine and primaquine are used for the treatment and prophylaxis of _____

Answer 11

malaria

Question 12

the quinolines interfere with the ability of ______ to detoxify hemoglobin

Answer 12

plasmodium

Question 13

primaquine is often used with clindamycin, which prevents ____ ____

Answer 13

protein synthesis

Question 14

the ______ may cause psychiatric issues (insomnia, vivid dreams, mood swings, etc), in addition to QT prolongation.

Answer 14

quinolines

Question 15

the benzimidazoles, which are separate from the azole antifungals, are used to treat _______

Answer 15

helminthes

Question 16

mebendazole is a ________

Answer 16

benzimidazole

Question 17

______ interferes with the elongation of the microtubules that are responsible for ________ _____ structure

Answer 17

parasitic cellular

Question 18

allergic reaction from the death of parasites is an ADR from ______

Answer 18

mebendazole