Miscellaneous

Question 1

ApoE issue?

Answer 1

Build up of remnants

Question 2

LPL or ApoC2 deficiency?

Answer 2

Build up of chylomicrons

Question 3

What are the 4 monoamines? Which are catecholamines? Indoleamine?

Answer 3

Serotonin, dopamine, norepinephrine, epinephrine.

Question 4

Which AA forms catecholamines? Indolamine?

Answer 4

Tyrosine. Tryptophan

Question 5

Catecholamine synthesis step one and product?

Answer 5

Tyrosine hydroxylase, DOPA.

Question 6

Catecholamine step 2 enzyme and product?

Answer 6

DOPA decarboxylase. Makes dopamine.

Question 7

Catecholamine step 3 enzyme and product?

Answer 7

Dopamine b hydroxylase. Norepinephrine

Question 8

Catecholamine step 4 enzyme and product? Needs what methyl donor?

Answer 8

Phenylethylnolamine N methyl transferase. Epinephrine. SAM

Question 9

Serotonin production steps?

Answer 9

Tryptophan hydroxylased and decarboxylased. Made in gut, carried in platelets. Constriction factor

Question 10

Serotonin breakdown product?

Answer 10

5 HIAA

Question 11

Dopamine breakdown product? NE and E?

Answer 11

Homovanillic acid. Vanillylmandelic acid

Question 12

MAO does what?

Answer 12

Degrades monoamines

Question 13

Carcinoid syndrome symptoms and cause?

Answer 13

Flushing, diarrhea, elevated 5HIAA. Gut tumor raising serotonin

Question 14

Pheochromocytoma cause and symptoms?

Answer 14

Adrenal medulla cancer. Palpitations, sweating, vanillylmandelic acid up

Question 15

What does norepinephrine activate?

Answer 15

Thermogenin

Question 16

Question about negative nitrogen balance is asking about what?

Answer 16

Essential amino acids

Question 17

What amino acid is essential with PKU?

Answer 17

Tyrosine

Question 18

Does the liver use ketone bodies?

Answer 18

No

Question 19

Where are glycerol kinase and g6phosphatase found?

Answer 19

Only in liver

Question 20

Where is Glut1 most important?

Answer 20

Blood brain barrier

Question 21

Where is Glut2 found?

Answer 21

Pancreas and liver. Low affinity

Question 22

How is Glut4 activated?

Answer 22

By insulin and exercise. Only in muscle and adipose.

Question 23

HMG CoA reductase is targeted by what?

Answer 23

Statins

Question 24

HMG CoA lyase makes what?

Answer 24

Ketones

Question 25

Malate made to pyruvate by malic enzyme produces what? What is other path that makes that?

Answer 25

NADPH? PPP

Question 26

What does cortisol induce?

Answer 26

Proteolysis