Membrane Lipids Flashcards
Are all membrane lipids diacylglycerols?
Yes
What is the core from which all phospholipids are formed?
Phosphatidic acid
Which phospholipid is deficient in ARDs?
Phosphatidyl choline
De Novo phospholipid synthesis activates what?
Phosphatidic acid derived from glycerol 3 phosphate. Then reacts with functional group.
Difference for salvage formation of phospholipid?
Activates functional group to attach to acid group.
What energy type is used to form activated precursors for phospholipid formation?
CTP
What do phospholipases do?
Remove fatty acid chains and replace them with different ones to replenish membrane.
What part of the body is rich in sphingosine?
The brain
What carbon in sphingosine has a hydroxyl group to allow attachments?
Carbon 1
What does ceramide do?
Membrane lipid that can produce gangliosides, has two chains attached.
What is sphingomyelin the counterpart of?
Phosphatidylcholine
What is a glycosphingolipid?
A ceramide with a sugar at carbon 1
How are blood types related to sphingolipids?
A and B formed from H, which is sphingolipid. Type O needs homozygous inactive allele
Sphingolipid degradation diseases?
Tay-Sachs(hexoaminidase), Gauchers(b glucosidase), Niemann-Pick(sphingomyelinase)
Why are bile acids amphipathic?
Their hydroxyls are away from the plane
