Lipid Transport Flashcards
Basic lipoprotein particle makeup?
Apoprotein, phospholipid and cholesterol surface. Cholesterol esters and triglycerides in center
Where are chylomicrons made, and what are they rich in?
In the small intestine, rich in triglycerides
Where are VLDL made and of what?
In liver, with high triglycerides and low protein
Where are LDLs made and of what?
In the blood from VLDL, lot of protein and cholesterol.
Where are HDL made and of what?
In liver and small intestine, highest in protein
Function of chylomicrons?
Transport dietary triglycerides to tissues
Function of VLDL?
Transport triglycerides made in liver to tissue for storage.
Apoprotein 1 function?
Activates LCAT in HDL
ApoB types and function?
Apo48- structural in chylomicrons
Apo100- structural in VLDL and LDL, binding domain to allow LDL endocytosis
ApoCII function?
Activates lipoprotein lipase. Goes from HDL to chylomicrons
ApoE function?
Mediate uptake of chylomicrons and attachments in liver. Goes from HDL to chylomicrons and VLDL.
Chylomicrons cycle?
Released into lymph, give up triglycerides in capillaries via LPL. Remnants go to liver and recycled as VLDL
LDL main function?
Transport cholesterol to tissues for membrane function.
How are LDL receptors on cell surfaces regulated?
More cholesterol lowers receptors
HDL importance?
Hands off proteins to other lipoproteins. Also transfers cholesterol esters made by LCAT to remnants to go to liver.
