Gluconeogenesis Flashcards
How many ATP does gluconeogenesis require?
6
What impact does metformin have on gluconeogenesis?
It blocks it by activating AMP kinase
Where does gluconeogenesis take place?
Liver (little in kidney and small intestine)
What materials can feed gluconeogenesis?
Lactate, glycerol, amino acids, propionate. Glycerol and propionate minor
How much energy for cardiac tissue comes from fatty acid oxidation?
70%
What effect does gluconeogenesis have on blood sugar levels?
Raises it
Which two amino acids cannot provide carbon for gluconeogenesis?
Leucine and Lysine
Where does glycogenolysis take place?
Liver and muscle. Only liver releases glucose to blood stream
Step one in glycolysis reversed by what enzyme in gluconeogenesis?
Glucose 6 phosphatase
Step three of glycolysis reversed by what enzyme in gluconeogenesis?
F1,6 bisphosphatase
Step 10 of glycolysis is reversed by what enzymes in gluconeogenesis? How?
Pyruvate carboxylase and PEPCK. Pyruvate to oxaloacetate to PEP. Second reaction uses GTP
What cofactor do all carboxylases need? How is it reduced?
Biotin (except one VitK dependent), by eating raw eggs
What effect does F26BP have on gluconeogenesis? AMP? cAMP?
It inhibits it by activating PFK1
Inhibits
Increases
Cori cycle
Muscle- glucose to pyruvate to lactate
Liver- reversed
Glucose alanine cycle
Same as cori but alanine for lactic acid
