Fructose And Galactose

Question 1

First enzyme and product of fructose metabolism

Answer 1

Fructokinase. Makes F1P

Question 2

Second step enzyme and product of fructose metabolism

Answer 2

F1 phosphate Aldolase. Produces dihydroxyacetone P (glycolysis step 5 via isomerase) and glyceraldehyde.

Question 3

Step three enzyme and product of fructose metabolism

Answer 3

Triose kinase. Makes glyceraldehyde 3 phosphate (intermediate step 5)

Question 4

Is fructose conversion to fat regulated and why?

Answer 4

No, bypasses PFK1

Question 5

Hereditary fructose intolerance

Answer 5

Accumulation F1P. Deficiency in the aldolase. Hypoglycemia from stimulation of glucokinase. Gout

Question 6

Galactose metabolism end result?

Answer 6

G6P.

Question 7

2 types of galactosemia. What are they, and what are they caused by?

Answer 7

Galactokinase deficiency- mild, late life cataracts.

Deficiency in step 2- liver damage, early cataracts, mental issues.

Question 8

Why do galactose metabolism issues cause cataracts? Where is galactose found?

Answer 8

Galactose reduced to galactitol by aldose reductase. Initiates cataracts. In milk