Miscellaneous

Question 1

Daptomycin Spectrum

Answer 1

Good: MSSA, MRSA, strept
Mod: enterococci (VRE)

Question 2

Daptomycin Dose

Answer 2

IV: 6-10 mg/kg q24h

Question 3

Daptomycin Renal

Answer 3

0-30: 6 mg/kg q48h

Question 4

Polymyxins

Answer 4

Polymyxins B, colistin

Question 5

Polymyxin Spectrum

Answer 5

Good: many GNR (A. baumannii, Pseudomonas)

Question 6

Polymyxin B Dose

Answer 6

IV: 15,000-25,000 units/kg/day divided q12h

Question 7

Polymyxin B Renal

Answer 7

NTE 15,000 units/kg/day

Question 8

Colistin Dose

Answer 8

IV/IM: 2.5-5 mg/kg/day in 2-4 doses, max/day: 5 mg/kg

Question 9

Colistin Renal

Answer 9

50-79: 3.8 mg/kg/day in 2 doses, 30-49: 2.5 mg/kg/day in 1-2 doses, 10-29: 1.5 mg/kg q36h

Question 10

Clindamycin Spectrum

Answer 10

Good: GP anaerobes, Plasmodium, S. pyogenes
Mod: Staph (not MSRA), GN anaerobes, Chlamydia, protozoa

Question 11

Clindamycin Dose

Answer 11

IV/IM :600-4800 mg in 2-4 divided doses, no renal

PO: 150-450 mg q6h

Question 12

Metronidazole Spectrum

Answer 12

Good: anaerobes, protozoa
Mod: H. pylori

Question 13

Metronidazole Dose

Answer 13

IV: 500-1000 mg q6-12h, max/day:4 gm, no renal
PO: 800-750 mg q8-12h

Question 14

Nitrofurantoin Spectrum

Answer 14

Good: E. coli, S. saprophyticus
Mod: Citrobacter, Kleb, Proteus, enterococci

Question 15

Nitrofurantoin Dose

Answer 15

PO: 100 mg BID

Question 16

Nitrofurantoin Renal

Answer 16

0-60: use with caution or avoid