Cephalosporins Part 1

Question 1

1st Gen Cephalosporins

Answer 1

Cefazolin, cephalexin,

Question 2

1st Gen Ceph Spectrum

Answer 2

Good: MSSA, strep
Mod: some enteric GNR

Question 3

Cefazolin Dosing

Answer 3

IV/IM: 1-3 g q6-8h, max/day: 12 g

Question 4

Cefazolin Renal

Answer 4

35-50: q8h, 11-34: half q12h, 0-10: half q18h

Question 5

Cephalexin Dosing

Answer 5

PO: 250-1000 mg q6h, max/day: 4 g

Question 6

Cephalexin Renal

Answer 6

15-29: 250 mg q8h; 5-14: 250 mg q24h; 1-4: 250 mg q48h

Question 7

2nd Gen Cephalosporins

Answer 7

Cefuroxime, cefoxitin

Question 8

2nd Gen Ceph Spectrum

Answer 8

Good: some enteric GNRs, H flu, Neisseria
Mod: strept, staph, anaerobes (cefoxitin)

Question 9

Cefuroxime Dosing

Answer 9

IV/IM/PO: 250-1500 mg q8-12h

Question 10

Cefuroxime Renal

Answer 10

10-30: q24h, 0-10: q48h

Question 11

Cefoxitin Dosing

Answer 11

IV: 1-3 g q4-8h, max/day: 12 g

Question 12

Cefoxitin Renal

Answer 12

30-50: 2 g q8h, 10-29: 2 g q12h, 5-9: 1 g q12h, 0-5: 1 gm q24h

Question 13

Ceph Combo

Answer 13

Ceftazidime/avibactam; cefolozane/tazobactam

Question 14

Ceph Combo Spectrum

Answer 14

Good: enteric GNRs, B. fragilis, strep, Pseudomonas

Question 15

Ceftolozane/tazobactam Dose

Answer 15

IV: 1.5 g q8h

Question 16

Ceftolozane/tazobactam Renal

Answer 16

30-50: 750 mg; 15-29: 375 mg

Question 17

Ceftazidime/avibactam Dose

Answer 17

IV: 2.5 g q8h

Question 18

Ceftazidime/avibactam Renal

Answer 18

31-50: 1.25 g q8h, 16-30: 0.94 g q12h, 6-15: 0.94 g q24h, 0-5: 0.94 g q48h