Macrolides and Folate Antagonists

Question 1

Macrolides

Answer 1

Erythromycin, clarithromycin, azithromycin

Question 2

Macrolide Spectrum

Answer 2

Good: atypicals, H flu, Moraxella, H pylori, Mycobacterium
Mod: strept

Question 3

Clarithromycin Dose

Answer 3

PO: 250-500 mg bid or 1 g daily

Question 4

Clarithromycin Renal

Answer 4

0-30: half dose

Question 5

Azithromycin Dose

Answer 5

IV: 500 mg q24h, no renal
PO: 250-1000 mg daily

Question 6

Erythromycin Dose

Answer 6

IV: 500-1000 mg q6h, max/day: 4 g. no renal
PO: 250-600 q6-12h

Question 7

Folate Antagonists

Answer 7

TMX/SMX, dapsone, sulfadiazine

Question 8

Folate Antagonist Spectrum

Answer 8

Good: MSSA (some MSRA), H flu, Stenotophmonas, PJP,
Mod: enteric GNRs, S. pneumo, Salmonella, Shigella, Nocardia

Question 9

TMP/SMX Dose

Answer 9

IV: 8-20 mg TMP/kg/day q6-12h
PO: 1-2 DS tabs q12-24h

Question 10

TMP/SMX Renal

Answer 10

15-30: half, 0-15: not rec, full q48h

Question 11

Dapsone Dose

Answer 11

50-300 mg PO daily in divided doses, no renal

Question 12

Sulfadiazine Dose

Answer 12

2-4 g/day PO in 3-6 divided doses