Aztreonam and Carbapenems

Question 1

Monobactams

Answer 1

Aztreonam; basically cetazidime with no PCN cross-reactivi

Question 2

Aztreonam Spectrum

Answer 2

Good: pseudomonas, most GNRs
Mod: acinetobacter

Question 3

Aztreonam Dose

Answer 3

IV/IM: 0.5-2 g q6-12h, max/day: 8 g

Question 4

Aztreonam Renal

Answer 4

10-30: half; 0-10: fourth

Question 5

Carbapenems

Answer 5

Imipenem/cilastatin, merropenem, ertapenem, doripenem

Question 6

Carbapenem Spectrum

Answer 6

Good: MSSA, strept, enteric and ESBL GNRs, Pseudomonas (not erta), Acinetobacter (not erta)
Mod: enterococci (not erta)

Question 7

Imipenem/cilastatin Dose

Answer 7

IV: 250-1000 mg q6-8h, max/day: 4 g

Question 8

Imipenem/cilastatin Renal

Answer 8

Based on total daily dose, CrCL and/or body weight

Question 9

Meropenem Dose

Answer 9

IV: 0.5-2 g q8h, max/day: 6 g

Question 10

Meropenem Renal

Answer 10

26-50: q12h, 10-25: half q12h, 0-10: half q24h

Question 11

Ertapenem Dose

Answer 11

IV: 1 g q24h

Question 12

Ertapenem Renal

Answer 12

0-30: 500 mg q24h

Question 13

Doripenem Dose

Answer 13

IV: 500 mg q8h

Question 14

Doripenem Renal

Answer 14

30-50: 250 mg q8h, 11-29: 250 mg q12h