Fluoroquinolones and 'Cyclines

Question 1

Fluoroquinolones

Answer 1

Ciprofloxacin, levofloxacin

Question 2

Cipro Spectrum

Answer 2

Good: enteric GNRs, H. flu
Mod: Pseudomonas, atypicals

Question 3

Levofloxacin Spectrum

Answer 3

Good: enteric GNs, S. pneumo, atypicals, H. flu
Mod: Pseudomonas, MSSA

Question 4

FQ Interactions

Answer 4

Decr. bioavailability with Ca, Fe, antacids, and multivitamins

Question 5

Levofloxacin Dosing

Answer 5

IV/PO: 250-750 mg q24h

Question 6

Levofloxacin Renal

Answer 6

20-49: 750 mg q48h, 0-20: 750 mg x 1 then 500 mg q48h

Question 7

Ciprofloxacin Dosing

Answer 7

IV: 200-400 mg q8-12h, PO: 500-750 mg

Question 8

Ciprofloxacin Renal PO

Answer 8

30-50: 500 mg q12h, 5-29: 500 mg q18h

Question 9

Ciprofloxacin Renal IV

Answer 9

0-30: q18h

Question 10

Tetracyclines

Answer 10

Tetracycline, doxycycline, minocycline

Question 11

Tetracycline Spectrum

Answer 11

Good: atypicals, rickettsia, spirochetes (H. pylori), Plasmodium
Mod: staph (MRSA), S. pneumo

Question 12

Tetracycline Dose

Answer 12

PO: 250-500 mg q6-12h,

Question 13

Doxycycline/Minocycline Dose

Answer 13

IV: 100-200 mg/day in 1-2 doses

Question 14

Tigecycline Spectrum

Answer 14

Good: atypical, enterococci (VRE), staph (MRSA), S. pneumo
Mod: most GNRs, anaerobes

Question 15

Tetracycline Renal

Answer 15

10-50: q12H, 0-10: q24h

Question 16

Tigecycline Dose

Answer 16

IV: 100 mg once then 50 mg q12h, no renal