MIDTERMS -part 2 - trypanosoma- BLOOD AND TISSUE FLAGELLATES Flashcards
specie of trypanosoma that is considered as brucei complex
trypanosoma gambiense
trypanosoma rhodesiense
mode of transmission for genus trypanosoma
vector bite
ingestion of infection feces of intermediate host by definitive host
entrance/inoculation of parasite through abrasion or break skin
insect vectors of genus trypanosoma
glossina flies
reduviid bug
glossina flies is also called as
tse tse flies
tse tse flies or glossina flies is for what species of trypanosoma
gambiense and rhodiense
reduviid bug is for what specie of trypanosoma
cruzi
species of trypanosoma that are called as african trypanosomiasis
brucei complex - gambiense and rhodiense
species of trypanosoma that iscalled as american trypanosomiasis
trypanosoma cruzi
other names of trypanosoma crzi
Schozitrypanum
cruzi
Trypanosoma
escomele
Trypanosoma
triatomae
geographical distribution of trypanosoma cruzi
Central & South
America
Aside from the
given mode of
transmission,
Trypanosoma cruzi
can be transmitted
through ___ that is specific only for Trypanosoma cruzi
blood
transfusion.
disease associated with trypanosoma cruzi
South American
Trypanosomiasis
general term of disease associated with trypanosoma cruzi infection
South American
Trypanosomiasis
Sleeping sickness
Sleeping sickness is scientifically or particularly known as
chagas’ disease
what is the clinical feature of the disease associated with trypanosoma cruzi
sleeping sickness
sleeping sickness is also called as
somnolence
2 stages of manifestation for trypanosoma for all species
- hemolymphatic
stage - meningoencephalitic
stage
the common name for the insect vector of trypanosoma cruzi
reduviid bug
reduviid bug is also called as
Triatomid bug
Assassin bug
Kissing bug
Cone nose bug
riduviid bug is also called as kissing bug because?
–it bites the
person near the lips
Scientific names for
reduviid bugs:
- Panstrongylus
megistus - Triatoma infestans
- Rhodnius prolixus
Mode of transmission for trypanosoma cruzi
- Bite of reduviid bug
which defecate at site
of inoculation - Accidental ingestion
of bug - Blood transfusion
infection site of stage 2 for trypanosoma disease
CNS
American
trypanosomiasis was
first described by
___ in
Brazil
in 1909
Carlos Chagas
The infection,
Chagas’ disease,
is caused by the
hemoflagellate
__
Trypanosoma cruzi
the disease is a
public health
threat in most Latin
American countries,
although cases due
to blood derivatives
or blood transfusion
has been reported
in non-endemic
regions.
chagas disease
trypanosoma cruzi,
In blood films, it can be
seen as what shape?
sickle shape,
twisted, letter C, S U.
a stage wherein the Parasite is settling in
blood or lymph
hemolymphatic stage
for trypanosoma cruzi, Main cause of death of the patient
is
Brain infection or
damage - Blockage of the artery
in the heart
Characteristics of a reduviid bug is
once it bite the human, it will _____ on the bite site
containing the parasite. Thus,
trypomastigote of the trypanoma
is transmitted through feces not
the saliva of an infected insect.
defecate
trypanosoma cruzi, There are times that it can
contaminate ocular mucosa
resulting to conjunctivitis and
edema of the eyelids known as
___
Romaña’s sign
The primary lesion of trypanosoma cruzi is in the form
of ___
Chagoma
A nodular lesion or
furuncle, usually called
____, can appear
at the site of
inoculation
chagoma
any infection of trypanosoma is crucial to diagnose and
treat it as early in the
___ stage
hemolymphatic
mode of diagnosis for trypanosoma cruzi
- Microscopic demonstration
of parasite stained blood
smear / lymphnode aspirate - Culture NNM medium
- serological
culture used for trypanosoma cruzi
NNM or NNN
serological test for trypanosoma cruzi
ELISA
drugs for trypanosoma cruzi
Primaquine
partially effective
Nifurtimox acute
cases
= there is no
entirely available
drug for tx./
prevention
of the disease
other name of trypanosoma gambiense
west African
trypanosomiasis
geographical distribution of Trypanosoma gambiense
Central & West
Coast
of Africa
disease associated to trypanosoma gambiense is called
gambian sleeping sickness
common name for the vector of T. Gambiense
tse tse fly - glossina spp
tse tse fly or glossina species
Scientific name:
1. Glossina palpalis
2. Glossina techinoides
It will indicate
that the
recovered
parasite is
trypanosoma
gambiense
due to the presence of what granule?
volutin granule
trypanosoma gambiense
lesions are in the form of ___,
which is similar to syphilis
chancre
signs for trypanosoma gambiense
Winterbottom’s sign
Kerandel’s sign
among the sign for trypanosoma gambiense
which one is for the enlargement of nodes>
Winterbottom’s sign
among the sign for trypanosoma gambiense
which one is associated with the first stage of disease in trypanosoma?
winterbottom’s sign
among the sign for trypanosoma gambiense
which one is associated with the 2nd stage of disease in trypanosoma?
Kerandel’s sign
among the sign for trypanosoma gambiense
which one is about the delayed sensation of pain?
kerandel’s sign
method of diagnosis for trypanosoma gambiense
- Microscopic examination
smear from lymph, blood &
CSF - Serological test
the serological test for gambiense is based on the detection of
anti-trypanosome antibodies
2 serological test for gambiense
A. immunofluorescence test
B. indirect hemagglutination
tes
drugs for trypanosoma gambiense
Pentamidine &
Suramin (very
effective if given
during
hemolymphatic
stage)
Tryparsamide 2-3
grams 15-20
weeks
Metarsoprol - for
late stage with
CNS involvement
a drug for trypanosoma gambiense if the late stage with cns is involve
Metarsoprol
habitats of trypanosoma gambiense
blood
lymph nodes
csf
connective tissue
intracellular space brain
lymph channels throughout the body
trypanosoma is geographycally distributed to
east africa
based on its location, trypanosoma rhodesiense’s disease is called
east african sleeping disease
Rhodesian Sleeping
Sickness
the difference in life cycle of Trypanosoma cruzi and trypanosoma brucei complex
in trypanosoma cruzi, instead of infecting salivary gland, the parasite will infect the hind gut
