Midterm Quiz Questions

Question 1

sarcoiodosis manifested by generalized activation and proliferation of macrophages which cause inflammation in the lymph nodes (lymphadenitis), lungs, and liver. To design anti-cytokine therapy, which of the following cytokines is best pharmacological target for treatment for this disease?

Answer 1

A. IFN-gamma

Question 2

3yo pink eye. adenovirus. most important in host defense against infection?

Answer 2

cytolytic T lymphocytes

Question 3

purified Igs are treated with pepsin and effector properties of Fc fraction tested. Which function is demonstrated?

Answer 3

A. activation of complement

Question 4

newborn midface hypoplasia and defects of great vessels of heart. Analysis reveals reduced CD4 T cells. which of the following is most likely underdeveloped in this patient?

Answer 4

E. Thymus

Question 5

7yo severe brochiectasis resulting from repeated respiratory infections caused by a variety of viruses. Lab tests establish that her clinical condition results from an MHC gene mutation (deficiency). This disease is consistent with which of the following changes in immune cells?

Answer 5

E. profound deficiency in CD8 t cells

Question 6

10yo girl evaluated for prolonged fever and cough following a 3 week visit to her grandparents in Russia. A TB skin test positive. Chest X ray nomad. Which aberrant anti-microbial responses in the patient may contribute to the subversion of the protective immunity leading to an active form of the disease?

Answer 6

poor response of CD8+ t cells due to low Ag presentation within class I MHC

Question 7

which cell marker is used to identify number of t cells in the

Answer 7

CD3

Question 8

following immune cells capable of antigen presenting within class II MHC

Answer 8

CD19+

Question 9

ctyokine question

Answer 9

IL4/IL5/ and IFN-gamma

Question 10

virus cells eliminated by

Answer 10

CD8

Question 11

pt symptoms of rare, isolate NK cell deficiency. best supports diagnosis?

Answer 11

cytomegalovirus and herpes

Question 12

perforin deficiency CNS. function of which immune cells affected?

Answer 12

CD8 and NK cells

Question 13

7 yo presents with immune deficiency characterized by recurrent infection of the upper and lower respiratory tract, low…..hyper IgM brother, IgG and IgA low

Answer 13

CD40L

Question 14

which of the following proteins is also involved in formation of immunological synapse. T helper and APC

Answer 14

CD4

Question 15

viral infection. which of the following immune mediators and molecules is most important for eradication of the pathogen in this patient?

Answer 15

perforin and granzymes

Question 16

26yo woman presents with complaints of cough, fever, night sweat, and weight loss over. tuberculosis which of following cytokines most important against intracellular pathogens?

Answer 16

IFN-gamma

Question 17

gram-negative bacteria

Answer 17

TLR4