Cytotoxic Cell-Mediated Immune Response

Question 1

Maturation of Ag-independent T cells occurs where?

Answer 1

in thymus; only stem cells from bone marrow

Question 2

Thymocytes are able to present self-antigens to what cells?

Answer 2

CD4 and CD8 allows for negative selection

Question 3

CD co-receptors bind to what?

Answer 3

MHC

Question 4

pathogen-specific T cells are made by what process?

Answer 4

clonal expansion

Question 5

what activates naive T cell and what occurs after that?

Answer 5

APC; proliferation

Question 6

Langerhan’s cells must move where to begin expressing B7?

Answer 6

lymph node

Question 7

only what kind of DC can stimulate T cell?

Answer 7

B7 positive

Question 8

What kind of cell does not express B7?

Answer 8

Langerhans’ cells

Question 9

In what area of lymph node is DC loaded with Ag?

Answer 9

parafollicular cortex

Question 10

How do naive t cells enter lymph node?

Answer 10

blood stream

Question 11

How are Ags delivered for T cells by activated DC?

Answer 11

afferent lymphatic vessel

Question 12

CD4 and CD8 co-receptors function to do what for Th and CTLs on proper MHC?

Answer 12

concentrate attention

Question 13

What is used as marker to count total T cells?

Answer 13

CD3

Question 14

Ag recognition prompts what process in T cells?

Answer 14

clustering of TCRs

Question 15

Activation of T cells initiates what process?

Answer 15

signaling cascade

Question 16

What 3 things are needed for T cell activation?

Answer 16

1. TCR
2. CD3
3. CD 4 or CD8

Question 17

Which co-stimulator has long enough cytoplasmic cell to transduce signal?

Answer 17

CD3

Question 18

B7 proteins bind to what on T cells?

Answer 18

CD28 receptor

Question 19

upon activation and co-stimulation what occurs to t cells?

Answer 19

proliferation and differentiation of T cells specific for bacterial protein

Question 20

What autocrine signal do T cells begin to produce upon activation?

Answer 20

IL2

Question 21

IL-2 is also known as?

Answer 21

T cell growth factor

Question 22

Naive cells lack what receptor?

Answer 22

IL-2R; activated express in large number

Question 23

stopped at slide

Answer 23

12

Question 24

start again at slide 14

Answer 24

but didn’t finish

Question 25

Upon second activation T cells secrete what other cytokines?

Answer 25

IFN-gamma + TNF or IL-4,5,10

Question 26

Where does re-stimulation occur?

Answer 26

T cell homing= go to tissue which the Ag-loaded dendritic cell arrived to in LN

Question 27

Which APCs involved i re-stimulation of arrived(re-homing) T cells?

Answer 27

Tissue macrophages

Question 28

do slide 15

Answer 28

sweet bro

Question 29

Which cytokines do T helper type 1 produce upon re-stimulation?

Answer 29

IFN-gamma, IL-2, TNF-beta

Question 30

Which cytokines do T helper type 2 produce upon re-stimulation?

Answer 30

IL-4, 5, 10

Question 31

What controls functional commitment of T helper cells?

Answer 31

Tissue macrophages and secretory products

Question 32

What is another name for the microenvironment for differentiation of T helper cells?

Answer 32

cytokine field

Question 33

What drives commitment toward Th1 cells?

Answer 33

macrophages and IL-12

Question 34

What drives commitment toward Th2 cells?

Answer 34

IL-4; or absence of IL-12

Question 35

Th1 cells are involved in which kind of immunity?

Answer 35

cell-mediated

Question 36

Th2 cells are involved in which kind of immunity?

Answer 36

humoral

Question 37

Activated T cells express which protein?

Answer 37

CD40L

Question 38

What is expressed by APC

Answer 38

slide 19