Cytotoxic Cell-Mediated Immune Response Flashcards
Maturation of Ag-independent T cells occurs where?
in thymus; only stem cells from bone marrow
Thymocytes are able to present self-antigens to what cells?
CD4 and CD8 allows for negative selection
CD co-receptors bind to what?
MHC
pathogen-specific T cells are made by what process?
clonal expansion
what activates naive T cell and what occurs after that?
APC; proliferation
Langerhan’s cells must move where to begin expressing B7?
lymph node
only what kind of DC can stimulate T cell?
B7 positive
What kind of cell does not express B7?
Langerhans’ cells
In what area of lymph node is DC loaded with Ag?
parafollicular cortex
How do naive t cells enter lymph node?
blood stream
How are Ags delivered for T cells by activated DC?
afferent lymphatic vessel
CD4 and CD8 co-receptors function to do what for Th and CTLs on proper MHC?
concentrate attention
What is used as marker to count total T cells?
CD3
Ag recognition prompts what process in T cells?
clustering of TCRs
Activation of T cells initiates what process?
signaling cascade
What 3 things are needed for T cell activation?
- TCR
- CD3
- CD 4 or CD8
Which co-stimulator has long enough cytoplasmic cell to transduce signal?
CD3
B7 proteins bind to what on T cells?
CD28 receptor
upon activation and co-stimulation what occurs to t cells?
proliferation and differentiation of T cells specific for bacterial protein
What autocrine signal do T cells begin to produce upon activation?
IL2
IL-2 is also known as?
T cell growth factor
Naive cells lack what receptor?
IL-2R; activated express in large number
stopped at slide
12
start again at slide 14
but didn’t finish
Upon second activation T cells secrete what other cytokines?
IFN-gamma + TNF or IL-4,5,10
Where does re-stimulation occur?
T cell homing= go to tissue which the Ag-loaded dendritic cell arrived to in LN
Which APCs involved i re-stimulation of arrived(re-homing) T cells?
Tissue macrophages
do slide 15
sweet bro
Which cytokines do T helper type 1 produce upon re-stimulation?
IFN-gamma, IL-2, TNF-beta
Which cytokines do T helper type 2 produce upon re-stimulation?
IL-4, 5, 10
What controls functional commitment of T helper cells?
Tissue macrophages and secretory products
What is another name for the microenvironment for differentiation of T helper cells?
cytokine field
What drives commitment toward Th1 cells?
macrophages and IL-12
What drives commitment toward Th2 cells?
IL-4; or absence of IL-12
Th1 cells are involved in which kind of immunity?
cell-mediated
Th2 cells are involved in which kind of immunity?
humoral
Activated T cells express which protein?
CD40L
What is expressed by APC
slide 19
