Midterm #2 - Systematic Review and Meta-Analysis Flashcards
1
Q
narrative reviews
A
- usually written by experts
- informal and subjective methods to collect and interpret info
- narrative summaries of evidence
2
Q
systematic review
A
- review of evidence on a clearly formulated question
- systematic and explicit methods to identify, select, and critically appraise relevant primary research
- extract and analyze data
3
Q
structured, systematic process steps (8)
A
- formulate question
- plan review
- comprehensive search
- unbiased selection and abstraction process
- critical appraisal of data
- synthesis of data
- interpretation of results
- reporting the review
4
Q
advantages of systematic reviews
A
- reduce bias
- replicability
- identify gaps in research
5
Q
limitations of systematic reviews
A
- results may still be inconclusive
- may be no trials/evidence
- poor quality trials
6
Q
answerable questions (PICO framework)
A
- description of Population
- an identified Intervention
- an explicit Comparison
- relevant Outcomes
7
Q
writing the review protocol
A
- ensuring transparency
- ensuring accountability
- avoiding duplicity
8
Q
selecting studies
A
- accurate records and track
- summary
- reasons for excluded articles
9
Q
purpose of meta-analysis
A
- increase power
- improve estimates of size of effects
- resolve uncertainty when reports disagree
9
Q
meta-analysis
A
- statistical technique
- combines the results of multiple scientific studies to arrive at a comprehensive conclusion
10
Q
steps of meta-analysis
A
- define clear question
- literature search
- data extraction
- statistical analysis
- interpretation
11
Q
odds ratio (OR)
A
- effect size
- measures association between an exposure and an outcome
12
Q
OR = 1.00
A
- no association between exposure and outcome
13
Q
OR>1.00
A
- positive association
- increases likelihood of an outcome
14
Q
OR<1.00
A
- negative association
- decreases the likelihood of an outcome
