Midterm 1 - Unit 1 Lecture 2 Flashcards

1
Q

what is membrane potential

A

difference in distribution of ions(charged atoms) inside and outside the cell

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2
Q

what are elements inside the cell

A

potassium (K+)
sodium (Na+)
chloride (Cl-)

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3
Q

what are the elements outside the cell

A

Lots of Na+ & Cl-
Some K+

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4
Q

what is the distribution of ions at resting state

A

more negative ions inside than outside the neuron

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5
Q

what is the quantitative value for resting membrane potential

A

-70 mV

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6
Q

what is an action potential

A

very rapid change in the membrane potential that occurs when a neuron is stimulated.

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7
Q

what triggers and action potential

A

If membrane voltage reaches threshold

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8
Q

what happens during an action potential

A

Membrane potential goes from the resting potential to some positive value (approx. +30mV)

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9
Q

why does the membrane potential change during an action potential

A

Due to sodium channel opening to allow an influx of Na+ ions inside the cell (Depolarization)

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10
Q

what is depolarization

A

the rapid rise in potential, an all-or-nothing event that is initiated by the opening of sodium ion channels within the plasma membrane

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11
Q

what is hyperpolarization

A

a change in a cell’s membrane potential that makes it more negative.

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12
Q

what is myelin

A

fatty substance covering axons allows faster conduction of nerve impulses

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13
Q

what are the nodes of ranvier

A

axonal segments that lack myelin, allowing the action to jump from node to node

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14
Q

what is a synapse

A

small gap between two neurons, where nerve impulses are relayed by a neurotransmitter, from a presynaptic terminal of one axon to the postsynaptic receptors of another

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15
Q

what happens during neurotransmitter release

A

Vesicles release neurotransmitters across synaptic cleft onto other neurons
Released neuro- transmitters bind to postsynaptic receptors, which in turn open ion- channels

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16
Q

what happens after neurotrasmitter release

A

Stimulation of receptors on postsynaptic membrane causes generation of synaptic (local) potential

17
Q

Are postsynaptic potentials positive or negative

A

can be both

18
Q

what is an EPSP

A

synaptic inputs that depolarize the postsynaptic cell, bringing the membrane potential closer to threshold and closer to firing an action potential

19
Q

what is an IPSP

A

synaptic inputs that hyperpolarize the postsynaptic cell, caused by the flow of negatively charged ions

20
Q

EPSP’s must summate to produce an action potential. true or false

A

true

21
Q

what are the two types of summations

A

spatial summation
temporal summation

22
Q

what is spatial summation

A

occurs when several weak signals from different locations are converted into a single larger one
inputs from many presynaptic neurons at once

23
Q

what is temporal summation

A

converts a rapid series of weak pulses from a single source into one large signal
input from one presynaptic neuron in quick succession

24
Q

what is convergence

A

multiple neurons influencing one neuron

25
Q

what is divergence

A

one neuron can influence multiple

26
Q

how is a Postsynaptic potential terminated

A

through reuptake(taken back to axonal terminal that released it
having the neurotransmitters destroyed

27
Q

cocaine blocks the reuptake of what neurotransmitter

A

dopamine

28
Q

how do most drugs that affect behaviour

A

by affecting synaptic transmission
drugs can interfere with the opening/closing of these ion channels
can block or inhibit the postsynaptic effect OR can facilitate them

29
Q

how does Ethanol (alcohol) affect synaptic transmission

A

facilitates postsynaptic (GABA) stimulation
keeps Cl- ions channels open for longer periods of time
i.e., larger or longer IPSP