Microbiology: Viruses Flashcards
which capsid virus causes malignant change from inserting a particular type of DNA that promotes growth of host cells & how does it spread
human papillomavirus (HPV) → spread via close contact
which virus produces acute, lytic infection in epidermal cells of mucous membranes & how does it spread
adenovirus → airborne or spread via direct contact with droplets
some serotypes of adenovirus cause what (relative to the eye)
epidermic keratoconjunctivitis
how are herpes viruses spread
close physical contact & exchange of bodily fluids
describe the herpes virus life cycle
alternates between lytic infection & latent infection
what are the stages of herpes simplex 1
1) enters host cell & replicates at its peripheral sites (eyes, skin, mucosa)
2) spreads to axonal terminals of sensory neurons
3) transports to neuronal cell bodies & autonomic ganglia
4) latency in ganglia
5) reactivation with production in ganglia of infectious virus & anterograde transport to peripheral site of primary infection
describe the primary & secondary infection of herpes simplex 1
primary infection usually in childhood
secondary infection is a reactivation of latent virus
primary & secondary infection of varicella zoster
primary infection → chickenpox
reactivation → herpes zoster (shingles)
how can varicella zoster be reactivated
from concurrent illness, immunosuppression, or radiotherapy
how does varicella zoster maintain its latent state
cell-mediated immunity
what is the most common pox virus that causes ocular infection
molluscum contagiosum
how is molluscum contagiosum spread, and who is it most common in
most common in children & spread by direct contact
usually sexually transmitted in adults
coronavirus is what type of virus
+ssRNA virus
HIV is what type of virus & how does it work
retrovirus → uses reverse transcriptase to insert itself into host genome
varicella zoster establishes latency in which ganglia
trigeminal, lumbar & cervical
