Microbiology - Antifungals Flashcards
1
Q
What are some different classes of antifungals?
A
- Polyene
- Azole
- Terbinafine
- Flucytosine
- Echinocandin
2
Q
What is an example fo Polyene, its target and indication?
A
e.g. Amphotericin
Target: Cell membrane integrity
Indication: Yeast
3
Q
What is an example of Azole, its target + indication?
A
e.g. fluconazole
Target: Cell membrane synthesis
Indication: Yeast
4
Q
What is Terbafine’s target + indication?
A
Target: Cell membrane
Indication: Mould (vs dermatophytes)
5
Q
What is Flucytosine’s target?
A
Target: DNA Synthesis
6
Q
What is an example of Echinocandin, its target + indication?
A
e.g. Caspofungin
Target: Cell wall
Indication: Yeast (less toxic SE)
7
Q
What is Amphotericin B used in the treatment of?
A
- Cryptococcal meningitis
- Invasive fungal infection
