Microbiology 3 - Antimicrobial Agents 2 Flashcards
1
Q
What mnemonic can be used to help decide which antibiotic to use?
A
CHAOS Choice depends on the: Host charcteristics Antimicrobial susceptibilities of the Organism itself, as well as the Site of infection
2
Q
What is the Minimum Inhibitory Concentration and Breakpoint of an antibiotic useful for?
A
Working out sensitivity
MIC > breakpoint = resistant
MIC < breakpoint = sensitive
3
Q
What antibiotic should be given for gram pos cocci in clusters?
A
Flucloxacillin
4
Q
What antibiotic should be given empirically for gram neg cocci?
A
Ceftriaxone (could be meningococcus)
5
Q
What is the “eagle effect”?
A
Increasing the penicillin dose –> decreasing antibacterial activitity after a point
6
Q
How does the choice of antibiotic to treat UTI differ between community and hospital?
A
Community: nitrofurantoin/ trimethoprim
Hospital: cephalexin/ augmentin