Histopathology 5 - Gynaecological pathology Flashcards
What is salpingitis?
Infection of fallopian tubes
What are the possible complications of untreated salpingitis?
Adhesions
Abscesses
Peritonitis
Ectopic pregnancy
What are the high risk forms of HPV for cervical cancer?
16 and 18
Recall the stages of progression from normal cervical cells to cervical carcinoma
Normal T positive HPV (abnormal cells) CIN 1 (lower 1/3 of cells neoplastic) CIN 2 (2/3 of cells neoplastic) CIN 3 (full thickness neoplastic) Carcinoma
What do CIN and CGIN stand for, and what is the main difference between them?
CIN = cervical intraepithelial neoplasia
CGIN = cervical glandular intraepithelial neoplasia
CIN progresses to squamous cell carcinoma
CGIN progresses to adenocarcinoma
How does HPV lead to neoplatic transformation of cervical cells?
E6 and E7 viral proteins deactivate p53 and Retinoblastoma (tumour suppressor genes)
What age range is invited to cervical screening?
25-64
Which HPV strains are included in the quadrivalent vaccine?
6,11,16,18
What is leiomyoma of the uterus?
Smooth muscle cell tumour of the uterus
What is a fibroid?
Leiomyoma
How are fibroids classified?
As either intramural, submucosal or subserosal
What is the biggest risk factor for endometrial hyperplasia?
Persistent oestrogen
What is the difference between type 1 and 2 endometrial carcinomas?
Type 1: adenocarcinomas
Type 2: Serous/ clear cell carcinoma
What is the relative prevelance of type 1 vs type 2 endometrial carcinoma?
Type 1 = 80-85%
Type 2 = 10-15%
Recall the genetic associations of serous and clear cell endometrial carcinomas
Serous: p53 mutation
Clear cell: PTEN mutation