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PMU Biochemistry > Metabolism of Phospho- and Sphingolipids, Inositol Phosphates > Flashcards

Metabolism of Phospho- and Sphingolipids, Inositol Phosphates Flashcards

1
Q

What is the main group of lipids

A

TAG, GPL

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2
Q

Where are TAGs

A

.

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3
Q

What are Glycerphospholipids - structure, properties, where are they present

A

.

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4
Q

What are Sphingolipids - structure, properties

A

.

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5
Q

What are the membrane lipids

A

.

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6
Q

Give examples of a glycerophospholipid with specialised function

A

Dipalmitoylphosphatidyl Choline
Phosphatidylinositols
PAF - Platelet-activating factor

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7
Q

What is the structure of Dipalmitoylphosphatidyl Choline (Dipalmitoyl Lecithin)

A

.

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8
Q

How is Diplamitoylphosphatidyl Choline synthesised

A

.

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9
Q

What is the function of Diplamitoylphosphatidyl Choline

A

.

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10
Q

What are the different Phosphatidylinositols

A

.

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11
Q

What is PIP2

A

.

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12
Q

What is PIP3

A

.

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13
Q

What is the function of PAF (Platelet-activating factor)

A

.

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14
Q

What is the structure of PAF (Platelet-activating factor)

A

.

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15
Q

What are the 3 examples of Glycosphingolipids

A

.

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16
Q

What do the carbohydrate residue of Glycosphingolipids participate in

A

.

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17
Q

Describe Cerebrosides

A

.

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18
Q

Describe Gaucher Disease (in relation to cerebrosides)

A

.

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19
Q

Where are galactocerebrosides predominantly found

A

.

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20
Q

Where are glucocerebrosides predominantly found

A

.

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21
Q

What are the 3 Sphingolipids with specialised function

A

Globosides
Sulfatides
Gangliosides

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22
Q

What are Globosides

A

.

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23
Q

What are Sulfatides

24
Q

What are Gangliosides - description, where are they present and what is their role

25
Q

What are the sphingolipids involved in cell signalling

26
Q

What is the role of Sphingosine-1-Phosphate SP1

27
Q

What is the role of Ceramide-1-Phosphate C1P

28
Q

What are the roles of sphingosine and ceramide in cell signalling

29
Q

Where are ceramide derived from

30
Q

Describe the relationship of sphingolipids with Blood Type Antigens

31
Q

How are Glycophospholipids formed

32
Q

What are the substrates for Glycerphospholipids synthesis

33
Q

The substrates for Glycerphospholipids synthesis include FAs, what needs to happen to the FAs for the process to further

34
Q

How does the body obtain Glycerol-3-Phosphate

A

HINT: Glycerol Kinase, Glycerol-3-P DH

35
Q

How does the degradation of glycerophospholipids occur and why is it possible

36
Q

What are the different Phospholipases

37
Q

All Sphingolipids are synthesised on the base of what?

38
Q
  1. What is the first step of Sphingolipid synthesis
A

HINT: 18-C formed

39
Q
  1. What is the second step of Sphingolipid synthesis
A

HINT: amide linkage formed

40
Q
  1. What is the third step of Sphingolipid synthesis
A

HINT: double bond added

41
Q
  1. What is the fourth step of Sphingolipid synthesis
A

HINT: attachment of head group

42
Q

In what organelle does sphingolipids synthesise

43
Q

What degrades gangliosides

44
Q

What does pulmonary surfactant contain

45
Q

What is the function of pulmonary surfactant

46
Q

The deficiency of pulmonary surfactant in premature infants is known as - what is the treament

47
Q

What are the 2 diseases that involve phospholipids PL and Sphingolipids SpL

48
Q

What occurs in Multiple Sclerosis, in terms of PL and SpL

49
Q

What is Sphingolipidosis

50
Q

What enzyme is deficient in General Gangliosidosis

51
Q

What enzyme is deficient in Tay-Sachs disease

52
Q

What is Tay-Sachs disease and what are the symptoms

53
Q

What enzyme is deficient in Gaucher’s disease

54
Q

What is Gaucher’s disease and what are the symptoms

55
Q

What enzyme is deficient in Niemann-Pick disease

56
Q

What is Niemann-Pick disease and what are the symptoms

57
Q

What enzyme is deficient in Fabry’s disease

PMU Biochemistry (17 decks)

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