Free Oxidation and Heat Production

Question 1

What is Free Oxidation and what is it catalysed by

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Question 2

What is the significance of Free Oxidation

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Question 3

Describe Thermolysis

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Question 4

What are the regulators of heat exchange

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Question 5

Describe the body temp control system and how it is regulated

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Question 6

What is Thermogenesis - voluntary, non-voluntary and non-shivering

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Question 7

Thermogenesis - what occurs during the cold

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Question 8

How is suppressed cell respiration avoided

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Question 9

How is heat regulated in the cold

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Question 10

What occurs when noradrenaline binds to b-adrenergic receptors?

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Question 11

Why is FFA important?

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Question 12

Examples of CF and UCFs

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Question 13

Describe the Thermogenesis in BAT

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Question 14

Describe BAT

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Question 15

What affect does TSH have on BAT

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Question 16

What mechanism oxidises metabolites and by what enzymes

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Question 17

Describe MAO and DAO

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Question 18

What do oxygenases do

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Question 19

Where are monooxygenases found? example of one

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Question 20

Describe Cytochrome p450

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Question 21

What reactions do cc-p450 partake in?

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Question 22

Describe cytochromes

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Question 23

What is the reducing equivalent of CCs

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Question 24

What does it mean if CYPs are inducible

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Question 25

Where does Oxygen go for energy

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Question 26

Why is induction of CYPs in drugs important

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Question 27

What ROS can be formed from 1e- reduction of O2

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Question 28

What are the biological functions of ROS - +ve

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Question 29

What are the biological functions of ROS - -ve

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Question 30

ROS in carcinogenesis

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Question 31

How are ROS generated?

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Question 32

What are the exogenous factors that cause ROS

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Question 33

Describe NO synthesis (NO synthase) - what cofactors are needed, what red. equivalent

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Question 34

What biological role does NO have

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Question 35

What biological role does NO have

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Question 36

Describe NOS

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Question 37

What are the 2 reactions in which ROS/RNS are functional products

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Question 38

What is the structure of NADPH oxidase and where it is localised

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Question 39

What cytochrome does NADPH oxidase include

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Question 40

What happens when CC-b558 is activated in NADPH oxidase

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Question 41

What is CC-b558 composed of

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Question 42

What activates NADPH-oxidase - what regulates this activation

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Question 43

What is the role of PLC-Y

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Question 44

What messengers occur after PLC-Y is activated and what do they do

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Question 45

What is the role of PKC

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Question 46

in what cells are NADPH - oxidases located

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Question 47

What is the role of myeloperoxidase MPO and where is it localised

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Question 48

Describe the deficiency of NADPH oxidase

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Question 49

Describe the deficiency of MPO

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Question 50

Describe the mechanisms and factors preventing the generation of ROS

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Question 51

Name the 5 mechanisms and factors detoxifying the free radicals - examples of each

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Question 52

Describe the short e- transport chain

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