Metabolism of ethanol Flashcards
Ethanol is soluble in (water/lipid)
both
Ethanol is ___ acting
fast
Small portion of ingested ethanol is metabolized in the ______ digestive track
upper
Most ethanol is metabolized in the _____
liver
Most harm via ethanol is done to ______
liver
What chemical specifically is the source of alcohol toxicity?
Acetaldehyde
Low Km can metabolize ____ concentrations of ethanol and vice versa
low
ALDH1
ALDH2
ALDH3
ALDH4
Responsible for >80% of acetaldehyde metabolism in liver mitochondria
ALDH2
ALDH1
ALDH2
ALDH3
ALDH4
Responsible for remaining acetaldehyde in liver cytosol
ALDH1
People w/ ADH___ produce more acetaldehyde after drinking alcohol
ADH1B2
People w/ ADH___ metabolize less acetaldehyde after drinking alcohol
ALDH22
What is the energy economics of ethanol oxidation?
13 ATPs
An alternate route for ethanol oxidation in the liver microsomal ethanol oxidizing system including (insert location)
endoplasmic reticulum
What is bad about the alternate route of ethanol oxidation?
Produces secondary toxic materials such as acetaldehyde + free radicals
The alternate route for ethanol oxidation is catalyzed by cytochrome P450 oxidases mainly _____
CYP2E1
