Metabolism of ethanol Flashcards

1
Q

Ethanol is soluble in (water/lipid)

A

both

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2
Q

Ethanol is ___ acting

A

fast

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3
Q

Small portion of ingested ethanol is metabolized in the ______ digestive track

A

upper

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4
Q

Most ethanol is metabolized in the _____

A

liver

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5
Q

Most harm via ethanol is done to ______

A

liver

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6
Q

What chemical specifically is the source of alcohol toxicity?

A

Acetaldehyde

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7
Q

Low Km can metabolize ____ concentrations of ethanol and vice versa

A

low

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8
Q

ALDH1
ALDH2
ALDH3
ALDH4

Responsible for >80% of acetaldehyde metabolism in liver mitochondria

A

ALDH2

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9
Q

ALDH1
ALDH2
ALDH3
ALDH4

Responsible for remaining acetaldehyde in liver cytosol

A

ALDH1

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10
Q

People w/ ADH___ produce more acetaldehyde after drinking alcohol

A

ADH1B2

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11
Q

People w/ ADH___ metabolize less acetaldehyde after drinking alcohol

A

ALDH22

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12
Q

What is the energy economics of ethanol oxidation?

A

13 ATPs

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13
Q

An alternate route for ethanol oxidation in the liver microsomal ethanol oxidizing system including (insert location)

A

endoplasmic reticulum

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14
Q

What is bad about the alternate route of ethanol oxidation?

A

Produces secondary toxic materials such as acetaldehyde + free radicals

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15
Q

The alternate route for ethanol oxidation is catalyzed by cytochrome P450 oxidases mainly _____

A

CYP2E1

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16
Q

What is the energy economics of ethanol oxidation thru the alternate route?

A

About 7 ATP