Metabolism 62 Flashcards
1
Q
What are three different things that Cholesterol can be converted into?
A
- Steroid hormones
- Bile Salts
- Cholesterol Ester
2
Q
What is packaged into VLDL’s?
A
- Synthesized Cholesterol
- TAGs
3
Q
Name the most important intermediate in Cholesterol biosynthesis.
A
Mevalonate
4
Q
What enzyme mediates cholesterol biosynthesis?
A
HMG-coA reductase
5
Q
What are the intermediates leading to cholesterol?
A
- Mevalonate, Farnesyl, Squamate, Lanosterol, Cholesterol
- Most Flowers Smell Like Colons
6
Q
What inhibits HMG-coA reductase?
A
- Mevalonate
- AMP
- Glucagon
- Cholesterol
7
Q
What activates HMG-coA reductase?
A
Insulin
8
Q
What are the different levels of regulation for HMG-coA reductase?
A
- Transcriptional
- Translational
- Enzyme stability
- Phosphorylation
9
Q
What’s the enzyme for conversion of cholesterol to bile acids?
A
7 alpha hydroxylase
10
Q
What’s the enzyme for conversion of cholesterol to ACAT?
A
ACAT
