Metabolism 58

Question 1

Four enzymes required to reverse the irreversible steps of glycolysis

Answer 1

• Pyruvate Carboxylase
• PEP Carboxylase
• Fructose-1,6-biphosphate
• Glucose 6 Phosphatase

Question 2

Describe the Glucose-Lactate (Cori) cycle

Answer 2

• the lactate from RBCs and skeletal muscles travel through blood into liver
• in liver, lactate serves as substrate for gluconeogenesis with 6 ATP

Question 3

Describe the Glucose-Alanine (Alanine) cycle

Answer 3

• Alanine from blood travels to liver
• the alanine is broken down and turned into glucose with 6 ATP
• the alanine is also made into urea with 4 ATP

Question 4

Name the Gluconeogenic precursors (4)

Answer 4

• Lactate
• Amino acids
• Glycerol

Question 5

Glycerol Pathway to Glucose

Answer 5

• Glycerol to Glycerol 3 phosphate by Glycerol kinase
• next, Dihydroxyacetone phosphate by Glycerol 3 phosphate dehydrogenase
• sometimes converted into Glyceraldehyde 3 phosphate along the pathway