Metabolism 57 Flashcards
1
Q
Acronym for Citric Acid Cycle (CAC)
A
-Aye, Can I Keep Selling Sex For Money Officer
2
Q
Citric Acid Cycle substrates
A
- Acetyl CoA
- Citrate
- Isocitrate
- alpha-Ketoglutarate
- Succinyl CoA
- Succinate
- Fumarate
- Malate
- Oxaloacetate
3
Q
Products of molecules reduced in the CAC
A
- 3 NADH
- 1 FADH2
- 1 GTP
4
Q
Where does the CAC take place?
A
-mitochondria matrix & inner membrane
5
Q
Each cycle of CAC generates
A
9 ATP and 1 GTP
6
Q
Re-oxidation values of molecules
A
3 NADH at 2.5 ATP
1 FADH at 1.5 ATP
7
Q
Fine control of CAC (Isocitrate Dehydrogenase)
A
- Activated by ADP
- Inhibited by NADH & GTP
8
Q
Fine control of CAC (alpha-ketoglutarate)
A
- Activated by Ca2+
- Inhibited by NADH, Succinyl coA, ATP, and GTP
9
Q
Course control of CAC
A
- ADP
- NAD+/NADH
- FAD/FADH2
- Acetyl CoA
- Oxaloacetate
10
Q
Fumarase deficiency
A
- Encephalopathy & Dystonia
- autosomal recessive
- increased urinary excretion of CAC intermediates
11
Q
Fluoroacetate
A
converted to Fluorocitrate which inhibits aconitase stopping CAC
