Metabolism 59

Question 1

Different fates of glycogen degradation in muscle and liver

Answer 1

-In liver, glycogen becomes glucose and is transported put into the bloodstream
In muscle, glycogen is broken down and used in glycolysis

Question 2

Important enzymes for glycogen synthesis

Answer 2

• glycogen synthase

- branching enzyme

Question 3

Important enzymes for glycogen degradation

Answer 3

• glycogen phosphorylase

- debranching enzyme (tranferase & 1,4 glucosidase)

Question 4

Which 3 secondary messengers activate glycogen phosphorylase?

Answer 4

• cAMP
• Ca2+
• PI

Question 5

Is glycogen phosphorylase active when it’s phosphorylated or un-phosphorylated?

Answer 5

phosphorylated

Question 6

Is glycogen synthase active when it’s phosphorylated or un-phosphorylated?

Answer 6

unphosphorylated

Question 7

What signal deactivates glycogen phosphorylase?

Answer 7

Insulin

Question 8

Allosteric effects on glycogen phosphorylase

Answer 8

• high AMP activates

- high glucose and ATP deactivates

Question 9

What de-phosphorylates glycogen synthase?

Answer 9

phosphoprotein phosphatase

Question 10

Allosteric effects on glycogen synthase

Answer 10

-high glucose 6 phosphate activates

Question 11

Glucose 6 Phosphate Dehydrogenase deficiency

Answer 11

• hemolytic anemia
• X linked pattern of inheritance
• increased bilirubin

Question 12

NADPH role in preventing RBC oxidative damage

Answer 12

-maintains glutathione in a reduced state