Metabolism Flashcards
Describes all of the chemical reactions that take place in an organism.
Metabolism
What is the goal of metabolism?
Convert initial substrate
A series of interconnected biochemical reactions that convert a substrate through a series of metabolic intermediates, eventually resulting in a final product or products
Metabolic pathway
Two types of metabolism:
Anabolism and catabolism
The four general stages in the biochemical
energy production:
Stage 1: Digestion
Stage 2: Acetyl group formation
Stage 3: Citric acid cycle
Stage 4: Electron transport chain and oxidative phosphorylation
Where does digestion begin?
Mouth
What is the end product of digestion?
- Glucose and monosaccharides
- Amino acids
- Fatty acids and glycerol
Where does acetyl group formation occurs?
Cytosol and mitochondria
The end product of acetyl group formation?
acetyl CoA and reduced coenzyme NADH
Where does citric acid cycle take place in?
Mitochondria
What is the end product of citric acid cycle?
CO2 and energy
In citric acid cycle, citrate is turned into?
Isocitrate
In citric acid cycle, Isocitrate is turned into?
a-ketoglutarate
In citric acid cycle, a-ketoglutarate is turned into?
Succinyl-Coenzyme A
In citric acid cycle, Succinyl-Coenzyme A is turned into?
Succinate
In citric acid cycle, Succinate is turned into?
Fumarate
In citric acid cycle, Fumarate is turned into?
Malate
In citric acid cycle, Malate is turned into?
Oxaloacetate
In citric acid cycle, Oxaloacetate is turned into?
Citrate
Where does electron transport chain occur?
mitochondria
The end product of electron transport chain
ATP
the molecule that makes energy available within all cells.
Adenosine triphosphate (ATP)
The energy currency of the cell
Adenosine triphosphate (ATP)
True or false: Adenosine is a nucleoside
True
What is ATP comprised of?
nitrogen-containing base (adenine), a sugar (ribose), and three phosphate groups
Organelles most responsible for energy conversions. They can also multiply and increase their numbers when energy demands increase.
Mitochondria
Catalysts that do not get incorporated into the products of their reaction.
Enzymes
Requires oxygen to metabolize glucose and produce ATP
Aerobic cellular respiration
Aerobic cellular respiration has three stages:
- Glycolysis.
- The citric acid cycle.
- The electron transport chain
Glucose has how many carbons
Six
Where does glycolysis occur?
Cytoplasm
Which steps in glycolysis uses 1 ATP each?
Steps 1 and 3
Which steps in glycolysis produce 2 ATP?
Steps 7 and 10
The first set of reactions animals use to harvest energy occurs in the cytoplasm.
Glycolysis
10-step metabolic pathway by which glucose is converted to two molecules of pyruvate (a C₃ molecule)
Glycolysis
End product of glycolysis?
Pyruvate
The control ponts of glycolysis:
Steps 1, 3, and 10
Both pyruvate kinase (Step 10) and phosphofructokinase (Step 3) are?
allosteric enzymes
How many ATP are produced in krebs cycle
2
How many ATP are produced during glycolysis and the net gain.
4; 2
How many ATP are produced in skeletal muscle and nerve cells
30
How many ATP are produced in heart and liver cells
32
Is the series of biochemical reactions in which the acetyl portion of acetyl CoA is oxidized to carbon dioxide and the reduced coenzymes FADH₂ and NADH are produced
Citric Acid Cycle
Also know as:
- Tricarboxylic acid cycle (TCA) - Presence of three carboxylate groups in citric acid
- Krebs cycle - Named after Hans Krebs who elucidated this pathway
Citric Acid Cycle
Krebs cycle is named after:
Hans Krebs
Important reactions in the citric acid cycle include:
Reduction and decarboxylation
In every turn of CAC it produces:
2 CO2, 1 ATP, 3 NADH, 1 FADH2
Series of biochemical reactions in which intermediate carriers aid the transfer of electrons and hydrogen ions from NADH and FADH₂
The Electron Transport Chain
Complex I of ETC:
NADH–coenzyme Q reductase
Complex II of ETC:
Succinate–coenzyme Q reductase
Complex III of ETC:
Coenzyme Q–cytochrome c reductase
Complex IV of ETC:
Cytochrome c oxidase
Two mobile electron carriers
Coenzyme Q and cytochrome c
Process by which ATP is synthesized from ADP using the energy released in the electron transport chain
Oxidative phosphorylation
Pairs of biochemical reactions that occur concurrently in which energy released by one reaction is used in the other reaction
Coupled reactions
is used in a versatile set of metabolic pathways—the pathways can do much more than metabolize glucose
Anaerobic cellular respiration