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Biochem > Metabolic enzyme regulation > Flashcards

Metabolic enzyme regulation Flashcards

1
Q

Inhibition of hexokinase

A

Glucose-6-phosphate (negative feedback)

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2
Q

Activation of PFK-1 (2)

A

Allosterically by AMP and fructose-2,6-BP

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3
Q

Inhibition of PFK-1 (2)

A

Allosterically by ATP and citrate

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4
Q

Activation of PFK-2

A

Insulin

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5
Q

Inhibition of PFK-2

A

Phosphorylation by PKA (glucagon and epinephrine)

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6
Q

Activation of pyruvate kinase (liver, kidney, RBC)

A

Allosterically by Fructose-1,6-BP (feed forward)

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7
Q

Inhibition of pyruvate kinase (Liver, kidney, RBC)

A

Allosterically by ATP

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8
Q

Inhibition of liver pyruvate kinase

A

Phosphorylation (via glucagon)

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9
Q

Allosteric inhibition of pyruvate dehydrogenase

A

Allosterically by NADH and acetyl CoA

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10
Q

Phosphorylation Inhibition of pyruvate dehydrogenase

A

Phosphorylation via PDH kinase (via NADH, acetyl CoA, ATP)

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11
Q

Activation of pyruvate dehydrogenase

A

Phosphorylation (PDH kinase) inhibited by ADP and pyruvate
PDH phosphatase activated by Ca2+ with exercise

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12
Q

Inhibition of citrate synthase

A

Citrate (negative feedback)

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13
Q

Inhibition of isocitrate dehydrogenase

A

NADH and ATP

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14
Q

Activation of isocitrate dehydrogenase (2)

A

Ca2+
Allosterically by ADP

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15
Q

Inhibition of alpha-ketoglutarate dehydrogenase (2)

A

NADH, succinyl CoA (negative feedback)

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16
Q

Activation of alpha-ketoglutarate dehydrogenase

A

Ca2+

17
Q

Activation of pyruvate carboxylase

A

Allosterically by acetyl CoA

18
Q

Activation of phosphoenolpyruvate carboxykinase (PEPCK)

A

Glucagon increases PEPCK transcriptional synthesis

19
Q

Inhibition of phosphoenolpyruvate carboxykinase (PEPCK)

A

Insulin decreases PEPCK transcriptional synthesis

20
Q

Inhibition of fructose-1,6-bisphosphatase

A

Allosterically by F-2,6-BP and AMP

Biochem (21 decks)

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