MEN tumors

Question 1

MEN

Answer 1

• Inherited diseases

* Tumors of endocrine glands leading to overproduction of the hormones

Question 2

Causes of MEN

Answer 2

1. genetic mutation
   • MEN 1 - tumour supressor gene on Chr 11
   - MEN type 1 tumor caused

• RET - protoncogene which becomes oncogene
- MEN type 2A and 2B caused

Question 3

MEN type 1 tumor

Answer 3

1. Parathyroid
• inc parathyroid hormone release
• excess Ca -> Calcium kidney stones
2. Pancreatic
i. Gastrinoma -> Gastrin -> HCL -> peptic ulcers
ii. Insulinoma -> Hypoglycaemia
iii. Glucagonoma -> hyperglycemia
3. Pituitary
 Adenoma - non cancernous tumors
i. Prolactinoma 
-> Galctorrhea
-> Gynecomastia in men
ii. GH excess
-> Gigantism in children or Acromegaly in adults

Question 4

MEN type 2A

Answer 4

1. Thyroid medullary Cancer
   - develops in everyone with disease
   - Cancer of C cells which produce calcitonin
2. Adrenal glands - Phepchryomocytoma
   - excess epinephrine and norepinephrine produces
   - high bp, sweating
3. Parathyroid adenoma

Question 5

MEN type 2B

Answer 5

• Thyroid medullary cancer
• Pheochromocytoma
• Multiple neuromas
- tumors of nerve tissue in the skin and mouth

Question 6

Type 1 MEN symptoms

Answer 6

Pituitary adenoma may;
press on brain tissue
•head aches
press on optic nerve
• vision problems

Question 7

Type 2A and Type 2B symptoms

Answer 7

1. Thyroid tumor - press near by organs in the neck causing

• Hoarseness, coughing, trouble swallowing

Question 8

Diagnosis

Answer 8

• Genetic testing