May 2, 2016 - SG11 - Abnormal Serum Potassium Flashcards
TTKG Calculation
TTKG = ( Urine K+ / Serum K+ ) / ( Urine Osm / Serum Osm )
Factors Influencing Potassium Movement
Beta-2 agonists - increase the efficiency of the Na/K ATPase by phosphorylating it which brings more potassium into the cell and therefore leads to hypokalemia.
Alpha-2 agonists - decreases the efficiency of the Na/K ATPase by dephosphorylating it which develops hyperkalemia.
Insulin - increases the efficiency of NHE1 which is a Na/H antiporter. More sodium enters the cell which can feed the Na/K ATPase, thereby bringing more potassium into the cell and leading to hypokalemia.
Digoxin - acts as a competitive inhibitor for K+ and therefore less enters the cell, resulting in hyperkalemia
Cell Lysis - ruptured cells leak potassium and results in hyperkalemia
New Cells - require potassium and suck it up, resulting in hypokalemia
Treatment of Hypokalemia
ECG to make sure this is not an emergency - if so, give IV potassium at a rate of 1 mmol/minute.
Low potassium leads to a lower potential inside the cell which takes it longer to repolarize after an action potential.
Crystals and AKI
Crystals building up inside the kidney such as uric acid crystals or calcium phosphate crystals can cause the kidneys to be plugged or damaged. Can result in blood and protein in the urine.
Treatment of Hyperkalemia
Give IV calcium
Give insulin and glucose
Give salbutamol (beta-2 agonist)
Give diuretics (that aren’t K-sparing)
Reduce intake
Give potassium chelators
Fluid Retention and Potassium
With dehydrated states the body is trying to retain sodium and cannot effectively excrete potassium. Also, it is holding onto chloride really well too. Potassium cannot effectively leave the principal cell.