Major Histocompatibility Complex: Part I

Question 1

Following accurate presentation of antigens to T lymphocytes, what two roles will these activated cells have?

Answer 1

• Protection against intracellular pathogens
  
  • Activation of other immune cells

Question 2

What complexes are associated with the presenation of antigens to T cells?

Answer 2

MHC’s or major histocompatibility complexes

Question 3

While discovered as a result for the source for graft rejection, what genes are responsible for the tissue’s survival or rejection?

Answer 3

Histo-compatibility or tissue genes

Question 4

Each cluster of MHC genes has at least 3 classes of genes. Which class is associated with the production of receptors for endogenous antigens?

Answer 4

Class I

Question 5

Each cluster of MHC genes has at least 3 classes of genes. Which class is associated with the production of receptors for exdogenous antigens found only on antigen presenting cells?

Answer 5

Class II

Question 6

Each cluster of MHC genes has at least 3 classes of genes. Which class is associated with the production of proteins, which include complement components?

Answer 6

Class III

Question 7

What subclasses of Class I receptors are highly polymorphic and are expressed on all nucleated cells?

Answer 7

Ia, Ib, and Ic

Question 8

What subclass of Class I receptors are associated with being located outside the MHC gene on an entirely different chromosome?

Answer 8

Id, they are also the least polymorphic

Question 9

If Class II loci encode for molecules that are found only on professional antigen presenting cells, what chains will they utilize to increase their diversity of products?

Answer 9

Alpha (for A) and beta chains (for B), which can pair to give distinct products

Question 10

If each individual organism’s MHC genes are being express co-dominantly, what does this mean?

Answer 10

That while an organism receives one MHC gene from each parent each, they both are being expressed at the same time

Question 11

How many MHC I genes should every individual have?

Answer 11

6, which will then express six different Class I antigens

Question 12

A set of MHC alleles present on a chromosome is called an -?

Answer 12

Haplotype

Question 13

MHC class I molecules are associated with presenting antigens to what T cells?

Answer 13

CD8+ T lymphocytes

Question 14

MHC class II molecules are associated with presenting antigens to which T cells?

Answer 14

CD4+ T lymphocytes

Question 15

What do the neurons, erythrocytes, and gametes have in common, in relation to antigen presentation?

Answer 15

They do not possess Class I MHC molecules

Question 16

Why are Class III MHC genes not associated with producing products associated with antigen presentation?

Answer 16

They do not produce receptors, but rather components associated with the immune response, e.g. complement proteins