Cellular Immune Response, Part II Flashcards
The functions of CD4+ effector cells are mediated by -?
Cytokines
What four subsets of TH cells develop from naive T cell activation and differentiation, which is also known as polarization?
TH1, TH2, TH17, and follicular helper T cells
IFN gamma, which is associated in ___________ activation and immunoglobulin production of ____, can cause -?
Macrophage
IgG
Tissue damage due to chronic infections and stimulated macrophages, and autoimmune diseases
What interleukins are associated with both the activation of Mast cells, macrophages, and Eosinophils, as well as IgE production?
IL-4, IL-5, and IL-13
What steps are involved in polarization?
Induction, Stable commitment, and Amplification
What induces the differentiation of naive T cells into TH1 cells?
Microbes that are either ingested by phagocytes, or those that activate phagocytes
Which TH cell subset forms the central reaction of cell-mediated immunity, as it is a majoe effector T cell population in host defense?
TH1 cells
What causes the differentiation of TH1 cells as a result of activated transcription factors?
IL-12 and IFN gamma made by dendritic cells, macrophages, and NK cells
What TF’s are associated with TH1 differentiation?
T-bet, STAT1, and STAT4
Th1 cells are responsible for what primary roles?
Activating macrophages and the production of IgG antibodies
IFN gamma has many roles, which include those involved with TH1 cells. What are those?
- Activates macrophages for phagocytosis
- Promotes IgG class switching
- Inhibits IgE class switching
- Amplifies TH1 cells, inhibits the other subsets
- Stimulates expression of MHC’s (I and II)
Therapeutical uses of IFN gamma include -?
Atopic dermatitis, Astrocytoma, Fibrosarcoma, Brain tumors
What receptors are utilized for activating macrophages by TH1 cells?
CD40L:CD40, and by IFN gamma
What causes the differentiation of TH2 cells?
IL-4, in response to helminths and allergens
What are the main cytokines secreted by TH2 cells?
IL-4, IL-5, and IL-13
