Macrolides, Tetracyclines, and Fluoroquinolones: A Deep Dive Flashcards
Give me some examples of some macrolides
What is the mechanism of action for macrolide antibiotics?
It is 50S
What is the spectrum of activity for these macrolides?
What is the dosing of macrolide antibiotics?
what are the clinical uses of the macrolides?
Tell me the PK (ADE) and formulations and administrations for macrolides
What are some Macrolide Adverse effects
What are some macrolide drug interactions?
What are the tetracyclines?
What is the mechanism of action for Tetracylcines?
What is the spectrum of activity for tetracyclines?
What are the pharmacokinetics to tetracycline? (ADE)
How do I dose Tetracyclines?
Only tetracycline needs renal dosing with CrCl < 50 and u would extend the interval from q12h to q24h
What are the adverse effects that come from tetracycline?
What drug interactions does tetracycline have?
Tell me about Tigecycline (Tygacil) and its mechanism of action.
What is tigecyline spectrum of activity? Note anything unique
it covers MRSA and VRE
Tell me about tigecycline’s pharmacokinetics.
Tigecycline’s adverse effects
Tell me about the newer tetracycline derivatives
Tell me about the fluorquinolones what are the drugs.
What is the mechanism of action for fluorquinolones?
It is bacterialcidal
Tell me about the FQ activity
What is the spectrum of activity for fluorquinlones? (2)
Tell me about the pharmacokinetics and pharmacodynamics of FQ
Give me a relative dosing range for the FQs
What are the adverse effects that come from FQs? (1)
Remember to avoid in children and pregnancy and lactation
What are some more adverse effects of FQs and its BBW? (2)
What are some rare adverse effects for FQs?
What is a cardiac adverse effect from FQs?
What are some drug interactions with FQs?
What are some agents known to prolong QTc interval?
