Macrolides, Tetracyclines, and Fluoroquinolones: A Deep Dive

Question 1

Give me some examples of some macrolides

Answer 1

Question 2

What is the mechanism of action for macrolide antibiotics?

Answer 2

It is 50S

Question 3

What is the spectrum of activity for these macrolides?

Answer 3

Question 4

Question 5

What is the dosing of macrolide antibiotics?

Answer 5

Question 5

what are the clinical uses of the macrolides?

Answer 5

Question 6

Tell me the PK (ADE) and formulations and administrations for macrolides

Answer 6

Question 7

What are some Macrolide Adverse effects

Answer 7

Question 8

What are some macrolide drug interactions?

Answer 8

Question 9

Question 10

What are the tetracyclines?

Answer 10

Question 11

What is the mechanism of action for Tetracylcines?

Answer 11

Question 12

What is the spectrum of activity for tetracyclines?

Answer 12

Question 13

What are the pharmacokinetics to tetracycline? (ADE)

Answer 13

Question 14

How do I dose Tetracyclines?

Answer 14

Only tetracycline needs renal dosing with CrCl < 50 and u would extend the interval from q12h to q24h

Question 15

What are the adverse effects that come from tetracycline?

Answer 15

Question 16

What drug interactions does tetracycline have?

Answer 16

Question 17

Question 18

Tell me about Tigecycline (Tygacil) and its mechanism of action.

Answer 18

Question 19

What is tigecyline spectrum of activity? Note anything unique

Answer 19

it covers MRSA and VRE

Question 20

Question 21

Tell me about tigecycline’s pharmacokinetics.

Answer 21

Question 22

Tigecycline’s adverse effects

Answer 22

Question 23

Tell me about the newer tetracycline derivatives

Answer 23

Question 24

Tell me about the fluorquinolones what are the drugs.

Answer 24

Question 25

What is the mechanism of action for fluorquinolones?

Answer 25

It is bacterialcidal

Question 26

Tell me about the FQ activity

Answer 26

Question 27

What is the spectrum of activity for fluorquinlones? (2)

Answer 27

Question 28

Tell me about the pharmacokinetics and pharmacodynamics of FQ

Answer 28

Question 29

Give me a relative dosing range for the FQs

Answer 29

Question 30

Question 31

What are the adverse effects that come from FQs? (1)

Answer 31

Remember to avoid in children and pregnancy and lactation

Question 32

What are some more adverse effects of FQs and its BBW? (2)

Answer 32

Question 33

What are some rare adverse effects for FQs?

Answer 33

Question 34

What is a cardiac adverse effect from FQs?

Answer 34

Question 35

What are some drug interactions with FQs?

Answer 35

Question 36

What are some agents known to prolong QTc interval?

Answer 36

Question 36