Beta-Lactam Antibiotics Penicillins Flashcards by Victor Lao

Q

What were the mechanisms of resistance for bugs?

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Q

What are the two component structures of beta lactams?

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Q

What is the difference between gram positive and gram negative bacteria?

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Q

What is the MOA of penicillins?

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Q

What are the mechanisms of resistance?

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Q

What are beta lactamases?

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Q

What are natural penicillins, aminopenicillins, and carboxy and ureido penicillins

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Q

What are beta lactamase inhibitors?

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Q

What is the spectrum of activities for “Natural” penicillins

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Q

Tell me about penicillinase resistant PCNs

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Q

What is the spectrum of activity for AminoPenicillins? (Ampicillin and Amoxicillin)

A

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Q

What is the spectrum of activity for AminoPenicillins with a betalactamase inhibitor? (Unasyn, Clavulanic Acid)

A

Acinetobacter and MAYBE b frag coverage

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Q

What is the spectrum of activity for Ureidopenicillin? (Pip/Tazo “zosyn”)

A

Acinetobacter, pseudomonas, and B. fragilis coverage

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Q

What are the pharmacokinetics for penicillin

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Q

How do beta lactams distribute in the body?

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Q

Give me the dosing for penicillins

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A

Q

Give me a run down for betalactamase inhibitor dosing

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A

Q

Give me the dosages for Unasyn and Zosyn

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A

Q

What are considerations to keep in mind when dose adjusting?

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A

Q

What are the implications of penicillin allergies?

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A

Q

What are some cutaneous clinical manifestation

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A

Q

What are IgE mediated reactions when it comes to penicillins?

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A

Angioedema and anaphylaxis is deadly

Q

Tell me about t cell mediated reactions

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A

Q

Whats the difference between allergic vs adverse reactions

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A

Always document ur findings btw

Tell me about the penicillin skin test and its contraindications

Tell me about drug challenge

Tell me about antibiotic desensitization

What are some adverse effects to penicillins I should watch out for

Jarisch-Herxheimer rxn from PCN treatment for syhphilis

Give me some drug interactions for piperacillin + aminoglycosides, and B-lactam x 2 combos

How do penicillins interact with oral contraceptives?