Beta-Lactam Antibiotics Penicillins Flashcards
What were the mechanisms of resistance for bugs?
What are the two component structures of beta lactams?
What is the difference between gram positive and gram negative bacteria?
What is the MOA of penicillins?
What are the mechanisms of resistance?
What are beta lactamases?
What are natural penicillins, aminopenicillins, and carboxy and ureido penicillins
What are beta lactamase inhibitors?
What is the spectrum of activities for “Natural” penicillins
Tell me about penicillinase resistant PCNs
What is the spectrum of activity for AminoPenicillins? (Ampicillin and Amoxicillin)
What is the spectrum of activity for AminoPenicillins with a betalactamase inhibitor? (Unasyn, Clavulanic Acid)
Acinetobacter and MAYBE b frag coverage
What is the spectrum of activity for Ureidopenicillin? (Pip/Tazo “zosyn”)
Acinetobacter, pseudomonas, and B. fragilis coverage
What are the pharmacokinetics for penicillin
How do beta lactams distribute in the body?
Give me the dosing for penicillins
Give me a run down for betalactamase inhibitor dosing
Give me the dosages for Unasyn and Zosyn
What are considerations to keep in mind when dose adjusting?
What are the implications of penicillin allergies?
What are some cutaneous clinical manifestation
What are IgE mediated reactions when it comes to penicillins?
Angioedema and anaphylaxis is deadly
Tell me about t cell mediated reactions
Whats the difference between allergic vs adverse reactions
Always document ur findings btw
Tell me about the penicillin skin test and its contraindications
Tell me about drug challenge
Tell me about antibiotic desensitization
What are some adverse effects to penicillins I should watch out for
Jarisch-Herxheimer rxn from PCN treatment for syhphilis
Give me some drug interactions for piperacillin + aminoglycosides, and B-lactam x 2 combos
How do penicillins interact with oral contraceptives?
