Advanced Pharmacology Notes: Gram-Positive Antibiotics Flashcards
What are oxazolindinones? what is the MOA? give me and example of them
50S inhibitor, Linezolid, and Tedizolid
What is the spectrum of activity for Oxazolindiones?
They are bacterialstatic
Tell me about the PK, and indication, and dosing for Linezolid and tedizolid
Linezolid is 600mg
What are the adverse effects and what is a big one for linezolid?
Linezolid ones usually occur 2 weeks after therapy
What are some drug interactions of linezolid and tidezolid
It is compatible with D5 and NS and also monitor for myelosyppression especially thrombocytopenia
Tell me about daptomycin and what is its MOA?
Bacterialcidal
What is the spectrum of activity for daptomycin?
Only gram positive (Works on MRSA , VRSA and even VRE) goated with the sauce
What is the PK/PD of dapto?
DOOOOO NOOTTT USEEE IN PNEUMONIAAA IT DOESNT WORK
NO WORK IN LUNGS REMEMBER THIS NO WORK IN LUNGS
adjust at crcl <30 ml/min
How do I dose Daptomycin?
What are the adverse effects of daptomycin?
What are the drug interactions of dapto?
Tell me about the administration of dapto, is it D5 or NS compatible?
HELLL NOOO ITS NS ONLY
Tell me about lipoglycopeptides and its MOA
Bacterialcidal cell wall inhibitor
What bugs are lipoglycopeptides used for?
Gram positive and they have MRSA, MRSE, and even VISA
No gram negs at all
What is the Pk and PD of telavancin, dalbavancin, and oritavancin
Telavancin can be D5 or NS the rest are D5 only
What adverse effects does Telavancin have?
No heparin co admin
What ADR and DDI does dalbavancin have?
What ADR and DDI does oritavancin have?
No heparin co admin
Tell me about rifampin and its MOA
What is the mechanism of resistance of rifampin and its spectrum of activity
(works on MRSA)
What are the PK/PD properties of rifampin?
What are the indications and dosing of rifampin
It is used as combo therapy never mono
What are the adverse effects of rifampin?
What are some DDIs to rifampin?
Orange discoloration of urine, sweat, tears. monitor for rash, and kidney pain, do not take with antacids
