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Infectious Disease > Advanced Pharmacology Notes: Gram-Positive Antibiotics > Flashcards

Advanced Pharmacology Notes: Gram-Positive Antibiotics Flashcards

1
Q

What are oxazolindinones? what is the MOA? give me and example of them

A

50S inhibitor, Linezolid, and Tedizolid

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2
Q

What is the spectrum of activity for Oxazolindiones?

A

They are bacterialstatic

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3
Q

Tell me about the PK, and indication, and dosing for Linezolid and tedizolid

A

Linezolid is 600mg

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4
Q

What are the adverse effects and what is a big one for linezolid?

A

Linezolid ones usually occur 2 weeks after therapy

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5
Q

What are some drug interactions of linezolid and tidezolid

A
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6
Q
A

It is compatible with D5 and NS and also monitor for myelosyppression especially thrombocytopenia

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7
Q

Tell me about daptomycin and what is its MOA?

A

Bacterialcidal

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8
Q

What is the spectrum of activity for daptomycin?

A

Only gram positive (Works on MRSA , VRSA and even VRE) goated with the sauce

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9
Q

What is the PK/PD of dapto?

A

DOOOOO NOOTTT USEEE IN PNEUMONIAAA IT DOESNT WORK

NO WORK IN LUNGS REMEMBER THIS NO WORK IN LUNGS

adjust at crcl <30 ml/min

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10
Q

How do I dose Daptomycin?

A
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11
Q

What are the adverse effects of daptomycin?

A
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12
Q

What are the drug interactions of dapto?

A
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13
Q

Tell me about the administration of dapto, is it D5 or NS compatible?

A

HELLL NOOO ITS NS ONLY

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14
Q

Tell me about lipoglycopeptides and its MOA

A

Bacterialcidal cell wall inhibitor

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15
Q

What bugs are lipoglycopeptides used for?

A

Gram positive and they have MRSA, MRSE, and even VISA

No gram negs at all

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16
Q

What is the Pk and PD of telavancin, dalbavancin, and oritavancin

A

Telavancin can be D5 or NS the rest are D5 only

17
Q

What adverse effects does Telavancin have?

A

No heparin co admin

18
Q

What ADR and DDI does dalbavancin have?

A
19
Q

What ADR and DDI does oritavancin have?

A

No heparin co admin

20
Q

Tell me about rifampin and its MOA

A
21
Q

What is the mechanism of resistance of rifampin and its spectrum of activity

A

(works on MRSA)

22
Q

What are the PK/PD properties of rifampin?

A
23
Q

What are the indications and dosing of rifampin

A

It is used as combo therapy never mono

24
Q

What are the adverse effects of rifampin?

A
25
Q

What are some DDIs to rifampin?

A
26
Q
A

Orange discoloration of urine, sweat, tears. monitor for rash, and kidney pain, do not take with antacids

Infectious Disease (16 decks)

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