Advanced Pharmacology Notes: Gram-Positive Antibiotics Flashcards

1
Q

What are oxazolindinones? what is the MOA? give me and example of them

A

50S inhibitor, Linezolid, and Tedizolid

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2
Q

What is the spectrum of activity for Oxazolindiones?

A

They are bacterialstatic

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3
Q

Tell me about the PK, and indication, and dosing for Linezolid and tedizolid

A

Linezolid is 600mg

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4
Q

What are the adverse effects and what is a big one for linezolid?

A

Linezolid ones usually occur 2 weeks after therapy

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5
Q

What are some drug interactions of linezolid and tidezolid

A
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6
Q
A

It is compatible with D5 and NS and also monitor for myelosyppression especially thrombocytopenia

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7
Q

Tell me about daptomycin and what is its MOA?

A

Bacterialcidal

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8
Q

What is the spectrum of activity for daptomycin?

A

Only gram positive (Works on MRSA , VRSA and even VRE) goated with the sauce

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9
Q

What is the PK/PD of dapto?

A

DOOOOO NOOTTT USEEE IN PNEUMONIAAA IT DOESNT WORK

NO WORK IN LUNGS REMEMBER THIS NO WORK IN LUNGS

adjust at crcl <30 ml/min

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10
Q

How do I dose Daptomycin?

A
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11
Q

What are the adverse effects of daptomycin?

A
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12
Q

What are the drug interactions of dapto?

A
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13
Q

Tell me about the administration of dapto, is it D5 or NS compatible?

A

HELLL NOOO ITS NS ONLY

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14
Q

Tell me about lipoglycopeptides and its MOA

A

Bacterialcidal cell wall inhibitor

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15
Q

What bugs are lipoglycopeptides used for?

A

Gram positive and they have MRSA, MRSE, and even VISA

No gram negs at all

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16
Q

What is the Pk and PD of telavancin, dalbavancin, and oritavancin

A

Telavancin can be D5 or NS the rest are D5 only

17
Q

What adverse effects does Telavancin have?

A

No heparin co admin

18
Q

What ADR and DDI does dalbavancin have?

19
Q

What ADR and DDI does oritavancin have?

A

No heparin co admin

20
Q

Tell me about rifampin and its MOA

21
Q

What is the mechanism of resistance of rifampin and its spectrum of activity

A

(works on MRSA)

22
Q

What are the PK/PD properties of rifampin?

23
Q

What are the indications and dosing of rifampin

A

It is used as combo therapy never mono

24
Q

What are the adverse effects of rifampin?

25
What are some DDIs to rifampin?
26
Orange discoloration of urine, sweat, tears. monitor for rash, and kidney pain, do not take with antacids