Aminoglycosides and Vancomycin: Advanced Clinical Pharmacology Notes

Question 1

What is the MOA for aminoglycosides?

Answer 1

Question 2

What is the spectrum of activity for aminoglycosides

Answer 2

Gentamicin does not work for P. aeruginosa anymore, with Tobra being the most active

Question 3

What is the mechanism of resistance?

Answer 3

Question 4

What are the pharmacodynamics of aminoglycosides? (1)

Answer 4

Question 5

What are the pharmacodynamics in regards to adaptive resistance and synergy?

Answer 5

Question 5

Explain to me the pharmacokinetics of aminoglycosides.

Answer 5

Question 6

What are the traditional doses and monitoring parameters?

Answer 6

Question 7

Tell me about aminoglycoside synergy dosing

Answer 7

Question 8

Tell me about extended interval / once daily dosing (rationale, dosing and monitoring)

Answer 8

Question 9

Tell me about the clinical data, exclusionary populations and when to use with caution for extended interval dosing.

Answer 9

Question 10

Question 11

Name a risk factor (adverse effect) of aminoglycosides? (1) go into detail

Answer 11

Question 12

Name a risk factor (adverse effect) for aminoglycosides (2) go into detail.

Answer 12

Question 13

Name a risk factor (adverse effect) of aminoglycosides? (3)

Answer 13

Question 14

Tell me about pregnancy dosing for aminoglycosides

Answer 14

Question 15

Tell me about vancomycin what kind of antibiotic is it?

Answer 15

Its been utilized more throughout the year

Question 16

Tell me about peptidoglycan and the mechanism of action for vancomycin.

Answer 16

Question 17

Tell me about vancomycin resistant bugs and how enterococci become resistant to the drug

Answer 17

Question 18

Tell me about VISA

Answer 18

Vancomycin intermediate staph aureus. Characterized by a thicker cell wall and is resistant to vanco

Question 19

What is the spectrum of activity for vancomycin?

Answer 19

Question 20

What are the therapeutic indication for vancomycin?

Answer 20

Question 21

What are the pharmacokinetics and how is it eliminated?

Answer 21

Question 22

What are the pharmacodynamics of vanco?

Answer 22

Question 23

Tell me about the administration and dosage options of vanco and go into some detail

Answer 23

Question 24

Go into detail about the therapeutic drug monitoring of vanco specifically trough and peak monitoring (1)

Answer 24

Question 25

Tell me about the ranges of therapeutic drug monitoring and the general recommendations for vancomycin (2)

Answer 25

Question 26

Tell me about therapeutic drug monitoring in this case the frequency of monitoring (3)

Answer 26

Question 27

Question 28

Question 29

Question 30

Adverse effects (1): What are the infusion related and red neck syndrome/redmans

Answer 30

Question 31

What is a common adverse effect of vancomycin (2)?

Answer 31

Question 31

What is a common adverse effect of vancomycin? (3)

Answer 31