Antibiotics: Sulfonamides, Pleuromutilins, and Urinary Antiseptics Flashcards by Victor Lao | Brainscape

Q

Tell me about sulfonamides (what is bactrim?)

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

How do the two ingredients work in bactrim?

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What happens when they combine is it now bacterialcidal or static?

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the mechanisms of resistance for bactrim

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the spectrum of activity for bactrim?

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the pharmacokinetcis of sulfamethoxazole

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the pharmacokinetics of trimethoprim

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are ADRs to bactrim

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the ADR crystalluria?

A

Crystalline deposits that can cause urinary disruption

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are some combination products ?

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Tell me about the dosage forms.

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

How do i dose bactrim?

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is Lefamulin and its spectrum of activity?

A

50S A & P binder

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

How is the efficacy of lefamulin described (time or AUC/MIC?)

A

AUC/MIC

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Tell me about nitrofurantoin.

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is nitrofurantoins MOA

A

Q

Are there any gene resistance with nitro?

A

Resistance via gene mutation seen in E.coli

Q

What is nitro’s spectrum of activity?

A

Q

What are the pharmacokinetics of nitro

A

Q

What are the adverse reactions for nitro?

A

Q

What are the drug interactions and dosing for nitro

A

Q

What is nitro specifically for and where is it active?

A

Q

Tell me about fosfomycin

A

Q

What is the MOA for fosfomycin?

A

stops Bacterial cell wall synthesis at early stage (stops enolpyruvate transferase MurA)

Q

How do bugs become resistant to fosfomycin?

A

Q

What is the spectrum of activity for fosfomycin?

A

NOT ACTIVE AGAINST ACINETOBACTER

Q

What are the pharmacokinetics to fosfomycin?

A

DO not give in renal adjustments as u need good kidneys for this drug.

Q

What ADRs does fosfomycin have?

A

Q

Tell me about da dosing for fosfomycin

A

Q

What is pivmecillinam

A

Brand name Pivya

Q

What is Pivya’s MOA?

A

Q

What is the mechanism of resistance for pivmecillinam?

A

this also includes mutations of betalactamase, efflux pumps, PBP mutations, and porin changes

Q

What is the beta lactamase inhibitor chart

A

Q

What are the pharmacokinetics for privya

A

Q

What is the spectrum of activity for privya?

A

Works against ESBL

Q

What are the ADRs and DDI for pivmecillinam?

A