Antibiotics: Sulfonamides, Pleuromutilins, and Urinary Antiseptics Flashcards
Tell me about sulfonamides (what is bactrim?)
How do the two ingredients work in bactrim?
What happens when they combine is it now bacterialcidal or static?
What are the mechanisms of resistance for bactrim
What is the spectrum of activity for bactrim?
What are the pharmacokinetcis of sulfamethoxazole
What are the pharmacokinetics of trimethoprim
What are ADRs to bactrim
What is the ADR crystalluria?
Crystalline deposits that can cause urinary disruption
What are some combination products ?
Tell me about the dosage forms.
How do i dose bactrim?
What is Lefamulin and its spectrum of activity?
50S A & P binder
How is the efficacy of lefamulin described (time or AUC/MIC?)
AUC/MIC
Tell me about nitrofurantoin.
What is nitrofurantoins MOA
Are there any gene resistance with nitro?
Resistance via gene mutation seen in E.coli
What is nitro’s spectrum of activity?
What are the pharmacokinetics of nitro
What are the adverse reactions for nitro?
What are the drug interactions and dosing for nitro
What is nitro specifically for and where is it active?
Tell me about fosfomycin
What is the MOA for fosfomycin?
stops Bacterial cell wall synthesis at early stage (stops enolpyruvate transferase MurA)
How do bugs become resistant to fosfomycin?
What is the spectrum of activity for fosfomycin?
NOT ACTIVE AGAINST ACINETOBACTER
What are the pharmacokinetics to fosfomycin?
DO not give in renal adjustments as u need good kidneys for this drug.
What ADRs does fosfomycin have?
Tell me about da dosing for fosfomycin
What is pivmecillinam
Brand name Pivya
What is Pivya’s MOA?
What is the mechanism of resistance for pivmecillinam?
this also includes mutations of betalactamase, efflux pumps, PBP mutations, and porin changes
What is the beta lactamase inhibitor chart
What are the pharmacokinetics for privya
What is the spectrum of activity for privya?
Works against ESBL
What are the ADRs and DDI for pivmecillinam?
