(M) Natural History and Spectrum of Disease; and The Levels of Disease Prevention Flashcards
refers to the progression of a disease process in an individual over time, in the absence of treatment
Natural History of Disease
untreated infection with HIV causes a spectrum of clinical problems beginning at the time of seroconversion (primary HIV) and terminating with AIDS and usually death.
This may take 10 years or more for AIDS to develop after seroconversion.
Example of Natural History of Disease
Natural History of Disease - T or F
Many, if not most, diseases have a characteristic natural history
T
may history ang isang disease <3
the time frame and specific manifestations of disease may?
vary from individual to individua
what is the influence of a disease
Influenced by preventive and therapeutic measures
If left untreated, a disease would evolve through a series of ?
Stages
what are the series of stages are meant when a disease is left untreated?
stages that characterize its natural history
if an intervention is applied to a disease, what would happen?
the natural history is modified
T or D
when the natural history is modified, it will not produce a typical clinical course for the condition
F (it will produce a typical….)
What are the components of natural history of disease timeline
- Stage of Susceptibility
- Stage of Subclinical Disease
- Stage of Clinical Disease
- Stage of Recovery, Disability or Death
When does the exposure happen?
After the stage of suceptibility
identify what stage of the disease process
patholofic changes
Stage of Subclinical Disease
Onset of symptoms?
after the Stage of Clinical Disease
may symptoms lang pero walang manifestation of diease
can be tested, to make sure <3
When does usual time of diagnosis occurs?
Between Stage of Subclinical and Clinical Disease
what is the final disease timeline?
Stage of Recovery, Disability, or Death
womp womp
May vary from person to person and are influenced by preventive and therapeutic measures
Natural History of Disease Timeline
per person to okay? okay
The natural history of diseases for descriptive purposes has two phase
- Prepathogenesis
- Pathogenesis
his is the phase before man is involved
wala pa sakit, agents is not inside me (host)
Prepathogenesis
T or D
everyone is in the period of pre-pathogenesis of many diseases because disease agents are present in the environment where man lives
T
di lang napapasukan??? or naaffect
Interaction of the agent, the host and environmental factors, the agent finally reaches man
Period of Pre-pathogenesis
Strong winds can transport anopheline mosquitoes from an endemic area to a distant non-malarious one, thus bringing into proximity the vectors and prospective hosts.
Period of Pre-pathogenesis
The host must be in the area when the mosquitoes are blown by the wind.
This phase includes the successful invasion and establishment of the agent in the host.
Pathogenesis
what needs in the period of pathogenesis for a disease to manifest?
Incubation .
Incubation Period dude
After a period of incubation, whereby the agent multiplies and develops, or gets absorbed and fixed in the tissues, sufficient tissue or physiologic changes may have taken place to produce detectable evidence of the disease process in man
clinical horizon
Stage when diagnosis can usually be made
Pathogenesis
Pathogenesis - T or F
The disease process may never reach the clinical horizon, or it may proceed until it terminates in recovery, disability, or death, or until it is interrupted by treatment
T
I have a lab result that is positive of Myobacterium TB, what does this represents
clue: evidence
clinical horizon
detectable evidence yung labe result
how many requirements for the successful invasion of the host by an infectious agent
6 six sais
Six requirements for the successful invasion - T or F
Conditions in the environment must be favorable to the agent or the agent must be able to adopt to the environment.
T
bobo mo kung mag F ka
Six requirements for the successful invasion - T or F
Suitable reservoirs are not needed
F
it must be present
Six requirements for the successful invasion - T or F
A cute host must be present
T
if susceuptible yung cute edi T
Six requirements for the successful invasion - T or F
Satisfactory portal of entry into the host
T
Six requirements for the successful invasion - T or F
Accessible portal of exit from the host
T
Six requirements for the successful invasion - T or F
Appropriate means of dissemination and transmission to a new host
T
The signs and symptoms will vary - T or F
Characteristics and dosage of the agent, and the duration of exposure of the host to it
T
The signs and symptoms will vary - T or F
Reaction of the liver of the host to the introduction of the agent
F (tissue)
di naman lagi liver bobo
The signs and symptoms will vary - T or F
Portal of entry and tissues unaffected
F (affected)
When the host is infected, it mobilizes its?
Defenses
fill in the blanks
The infectious agent on the other hand tries to (_ _ _ _ _ ) to overcome the host’s resistance, and may elaborate toxins.
multiply
what are the four reaction that can happen when the resistance of the host FIGHT!
- The host successfully wards off the pathogen
- Balance equilibrium
- Sub-clinical conditions.
- Full-blown clinical cases
In this condition, the forces of the agent and the forces of the host are equal so that both are not affected.
Balance Equilibrium.
the host becomes a healthy carrier who can easily spread the disease to others, and evade detection.
Inapparent infection
hese refer to reactions which are very mild that they escape detections. This can also result in a carrier state.
Sub-clinical Conditions
These cases may be typical or atypical
Full-blown Clinical Cases
What are the 2 sequence of event that can happen to a full blown Clinical Case
- Death
- Recovery (Complete, Disability or Defect, or Carrier)
Pre pathogenesis or Pathogenesis?
Stage of Susceptibility
Pre-Pathogenesis
Pre pathogenesis or Pathogenesis?
Stage of Subclinical Disease, Clinical Disease, and Recovery, Disability, or Death
Pathogenesis
the process of a natural history of disease starts with?
appropriate exposure to or accumulation of factors
sufficient for the disease process to begin in a susceptible host
if u see this card
check the example for exposure for natural history of disease
After the disease process has been triggered, what changes then occur without the individual being aware of them.?
pathological changes
stage of subclinical disease, extending from the time of exposure to onset of disease symptoms, is usually called
for infectious diseases
incubation period
stage of subclinical disease, extending from the time of exposure to onset of disease symptoms, is usually called
for chronic diseases
latency period
incubation period, what does the patient shows?
shows asymptomatic (no symptoms) or inapparent
same goes for latency period
The incubation period, may vary according to the following:
- Virulence, dose, and portal of entry
- Previous experience of the host and the state of natural resistance
- The inherent character of the organism itself
T or F
Although disease is not apparent during the incubation period, some pathologic changes may be detectable with laboratory, radiographic, or other screening methods
T
what Period
Most screening programs attempt to identify the disease process during this phase of its natural history
Incubation Period
T or F
Intervention at a late stage is likely to be more effective than treatment given after the disease has progressed and become symptomatic
F (early)
=
he onset of symptoms marks the transition from
subclinical to clinical disease
Most diagnoses are made during the stage
stage of clinical disease
T or F
Some disease process may never progress to clinically apparent illness
T
identifcation
Some disease process may never progress to clinically apparent illness. In others, the disease process may result in illness that ranges from mild to severe or fatal. This range is called
the spectrum of disease
the disease process ends with?
- Recovery
- Disability
- Death ( ^0^ )
Pathology produces some form of disease, a deviation from normal function in an organ or system.
Impairment
when atherosclerotic plaque narrows coronary arteries, the patient may experience angina and normal cardiac function is impaired.
when atherosclerotic plaque narrows coronary arteries, the patient may experience angina and normal cardiac function is impaired.
T or F
Impairments are always perceived by the patient, and screening tests are used to identify impairments of which the person is not aware.
F (are not always..)
used to identify impairments
Screening Test
screening test is used for?
to identify impairments of which the person is not aware
T or F
An impairment can, although does not necessarily, lead to a disability
T
Defined as “any restriction or lack (resulting from an impairment) of ability to perform an activity in the manner or within the range considered normal for a human being.
Disability
For instance if the patient’s narrowed arteries cause him chest pain and if this limits his ability to walk, he has a disability due to heart disease and angina.
Disability
T or F
an impairment cannot be corrected (medically, surgically or by a prosthesis), it always resulting to disability.
F (it can be correct, and not always result to disability
In its turn, disability may or may not limit the patient in performing his normal social roles.
Handicap