Lymphoma Flashcards
hodgkins arise from what cells
B-CELLS
hodgkins clinical pres
- REED STERNBERG
- giant conn tissue cell containing 1 or 2 large nuclei
- presence determines hodgkins or non-hodg
hodgkins staging system
ANN ARBOR
waldeyer’s ring (nose/mouth area) is composed of
- cervical
- preauricular
- occipital lymph nodes
spleen is the largest?
lymph node
hodgkins total nodal irradiation aka
extended field irradiation
hodgkins mantle fld blocks what?
- lungs
- humeral heads
- larynx
- cord
hodgkins subdiaphragmatic fld includes
- para-aortics
- spleen
hodgkins peds periaortic sup field border
T10
non-hod xrt sensitivity
sensitive to rad
hodgkins xrt dose for cure
40-50 Gy
hodgkins most common site
NECK & SLCV
hodgkins 1/3 present with ?
“B” symptoms
-enlarged spleen, abd, bony tenderness, pleural effusion
“B” symptoms are ?
- enlarged spleen
- abdominal & bony tenderness
- pleural effusion
hodgkins xrt fields treated
- ap/pa mantle fld
- ap/pa para-aortic
- tx of pelvis, retroperitoneal, inguinals
hodgkins xrt dose
- 35-40Gy w/o chemo
- 20-25 Gy w/chemo
hodgkins mantle ant field superior border
inf mandible
hodgkins mantle ant field inferior border
insertion diaphragm
hodgkins mantle ant field lateral border
axillary nodes
hodgkins mantle post field superior border
occipital nodes
hodgkins mantle post field inferior border
diaphragm (T9-10)
hodgkins mantle post field lateral border
axillary nodes
hodgkins mantle field CAX located
suprasternal notch
hodgkins subdiaphragmatic field inf border
L4-5 or bifurcation of aorta
hodgkins subdiaphragmatic field blocks what
- liver
- kidneys
- pelvic bone
- reproductive organs
hodgkins peds xrt dose
- low doses: 36-44 Gy gross disease or 30-36 Gy microscopic
- small vol
- RAD= TX OF CHOICE
hodgkins peds periaortic field inf border
L4/5
hodgkins peds periaortic field lat border
9-10 cm wide
hodgkins peds pelvis field sup border
L5
hodgkins peds pelvis field inf border
2cm below ischial tuberosities
hodgkins peds pelvis field lat border
2cm beyond pelvic inlet
non-hod xrt prognosis
only small portion obtain cure b/c of high prob of spread
non-hod xrt stage I/II low grade dose
35-45 Gy
non-hod xrt intermed stage regimen
chop followed by 30-35 Gy
non-hod xrt follicular & mantle dose
30-36 Gy boost 36-40 Gy
non-hod xrt TBI dose
palliation in advanced nodular lymphcytic lymphoma= 1.5 Gy for 5 wks