Lymphocytes Flashcards
What is another word for wbc
Leukocytes
What immune cells are innate
- macrophages
- granulocytes
- dendritic cells
- nk cells
What immune cells are adaptive
- b cells
- T cells
What are the three innate immune responses
Fast, non specific and generic
What innate body surface défenses do we have
Skin, hairs, one way urine flow
How does adaptive immunity work
It is antigen specific
What do the b cells do
Humoral immunity- relating to body fluid
What do T cells do
Cell mediated immunity- killing
What is the nucleus like of a lymphocyte
Large and relatively round that fills the cytoplasm
How big are lymphocytes
1.5 - 3.5 x 10^9/L
What is the life span of lymphocytes
Many years
What is the function of lymphocytes
Central role in the immune system as it divides into b and T cells
How big are neutrophils
2.5 - 7.5 x 10^9/L
How big are monocytes
0.2 - 0.8 x 10^9/L
How big are eosinophils
0.04 - 0.44 x 10^9/L
How big are basophils
0.01 - 0.1 x 10^9/ L
What are the surface layer proteins called
MCH - major histocompatibility complex
What encodes MCHs in humans
HLA human leukocyte antigen
What are the three populations of lymphocytes
Natural killer, b cells, T cells
Where are T cells made
The thymus
Where are MCH-1 found
On the surface of all nucleated cells
Where are MCH-11 found
On the surface of antigen presenting cells
What are the two types of T cells
Helper and cytotoxic
What MCH do cytotoxic cells recognise
MCH-1
What MCH do helper cells recognise
MCH-11
How to T cells kill
Apoptosis. Cell lysis by creating pores
What do t helper cells do
Help other immune cells become fully functional
Where are b cells made
Bone marrow
What are the role of b cells
Mount a specific immune response by producing antigen specific antibiotics
How do b cells recognise antigens
B cell receptor
What is the role of plasma cells
The production and secretion of an antigen specific antibody
What characteristics do plasma cells have
- extensive RER and Golgi apparatus
- lower levels of membrane bound antibodies
What do memory b cells do
Ensure a quick secondary response
