Lymph_Histology Flashcards

1
Q

encapsulated lymphoid tissues

A

thymus, tonsils, lymph nodes, and spleen

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2
Q

reticular cells

A

synthesize reticular fibers…type III collagen that makes supporting framework of lymphoid organs

can be phagocytic

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3
Q

diffuse lymphoid tissue

A

lymphoid tissue that is spread out or not encapsuled

GALT/BALT

Peyers patches

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4
Q

peyers patches location

A

usually in the ileum

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5
Q

primary lymphoid nodules

A

no germinal center, mainly resting B cells and dendritic/macros/reticulars

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6
Q

secondary lymphoid nodules

A

made in response to an antigenic challenge

have germinal center, that is core of resting B cells

mantle or periphery is darker and has plasma cells, resting B cells, memory B cells, dendritic, macro and reticular

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7
Q

lymph nodes functions

A

maintains and produces B and T cells by clonal expansion

primary location for filtration of lymph

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8
Q

lymph node structures

A

encapsulates, cortex/medulla, lymphoid nodules, and a hilum

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9
Q

hilum of lymph nodes

A

region where blood vessels can enter and leave, arterial and venous blood entering and leaving respectively

also has efferent lymphatic vessel for the lymph to leave

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10
Q

lymph node cortex

A

lymphoid nodules, subscapular and cortical sinuses (sinusoids)

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11
Q

cells in lymphoid nodules

A

mainly B cells

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12
Q

paracortex of lymph node

A

mainly T cells that enter in paracortex via high endothelial venules

known as thymus dependent area

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13
Q

contents of medulla of lymph node

A

medullary sinuses and cords

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14
Q

high endothelial venules

A

postcapillary venule…made by a simple cuboidal epithelium

where most of lymphocytes leave blood stream and enter the lymph node via diepadesis

typically found in the paracortex of lymph nodes

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15
Q

medullary sinus

A

endothelium lined spaces, receive lymph from the cortical sinuses

contain macrophages

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16
Q

medullary cords

A

have lymphocytes and plasma cells

17
Q

thymus function

A

maintains T cells, helps T cells mature

18
Q

thymus structure

A

encapsulated, has cortex and medulla

19
Q

epithelial reticular cells of thymus

A

pale cell that surrounds and extends the outer layer of the thymus… form meshwork within which T cells are tightly packed

synthesize many hormones for making T cells immunocompetent

20
Q

thymocytes in the thymus

A

respond to cytokines and become T cells, migrate from cortex to medulla as they mature

surviving T cells are naive and leave thymus to go to secondary lymphoid tissue

21
Q

blood thymus barrier

A

within the thymus cortex

makes immunologically protected region ensuring antigens in blood cannot reach the developing T cells in the cortex of the thymus

22
Q

components of the blood thymus barrier

A

capillary endothelium and basal lamina
perivascular connective tissue (macrophages)
thymic epithelial reticular cells and basal lamina

23
Q

medulla of thymus

A

have the mature T cells that are loosely packed so lighter stained

contains the Hassal Corpuscles

24
Q

Hassal corpuscles

A

in thymus medulla, whorl like accretions of epithelial reticular cells

keratinized, increase in number with age

25
spleen functions
maintains and produces B and T cells through clonal expansion filters blood stores RBCs and kills bad ones prenatla hematopoeisis
26
structure of spleen
encapsulated with hilum and lymphoid nodules no cortex or medulla
27
White pulp nodules in spleen
collections of B cells in the spleen
28
periarterial lymphatic sheaths
collections of T cells in the white pulp of the spleen
29
red pulp of spleen
interconnected network of sinusoids and splenic cords
30
blood flow route in the spleen
splenic artery to trabecular artery to central artert to pnicillar artery to eithe splenic sinusoids of splenic cords
31
central artery of spleen
artery that runs right through the white pulp of the spleen
32
penicillar artery of spleen
artery that takes blood from white pulp and into the red pulp of the spleen
33
sinusoids of the spleen
lined by specialized fusiform epithelial called stave cells is closed circulation
34
splenic cords of the spleen
loose connective tissue with plasma, reticular, blood and macrophage cells open circulation
35
marginal zone of spleen
where the blood first enters the spleen, space between white and red pulp has lots of APCs and macrophages location where T and B cells are sorted into correct spot
36
tonsil function
maintain and produce B cells combat antigens entering via nose or oral epithelia
37
tonsil types
pharygeal, palatine, and lingual tonsils
38
tonsil structure
encapsulated with lymphoid nodules no cortex/medulla and no hilum