AntigenInfo

Question 1

location of presentation for antigens in connective or epithelial tissue?

Answer 1

in lymph nodes

Question 2

location of presentation for antigens in blood?

Answer 2

in the spleen

Question 3

conventional dendritic cells location

Answer 3

tissues

Question 4

conventional dendritic cells TLRs

Answer 4

TLR 4, 5, 8

Question 5

conventional dendritic cells cytokines

Answer 5

TNF, Il-6, IL-12

Question 6

conventional dendritic cells function

Answer 6

induction of T cell response against most antigens

Question 7

plasmacytoid dendritic cells location

Answer 7

blood and tissue

Question 8

plasmacytoid dendritic cells TLRs

Answer 8

TLR 7 and 9

Question 9

plasmacytoid dendritic cells cytokines made

Answer 9

IFN a and b

Question 10

plasmacytoid dendritic cells function

Answer 10

antiviral innate immunity and induction of T cell response against viruses

Question 11

mature dendritic cells ability

Answer 11

able to present peptide antigens to naive T cells in lymph nodes

Question 12

dendritic cell role in Antigen presentation

Answer 12

can express MHC II, initates T cell response to protein antigens

Question 13

macrophages role in antigen presentation

Answer 13

inducibly expresses MHC class II, leads to effector phase of cell mediated immune response

Question 14

B lymphocytes role in antigen presentation

Answer 14

can express MHC class II, presents antigen to helper CD4+ cells

Question 15

what can B cells recognize?

Answer 15

proteins, nucleic acids, polysaccharides, lipids and small molecule

Question 16

what can T cells recognize?

Answer 16

must be very small peptide fragments, and relies on MHC to process an antigen into the small peptide fragments

Question 17

How does a T cell bind a peptide fragment?

Answer 17

it binds the fragment and the MHC component that it recognizes

Question 18

MHC Class I information

Answer 18

found in all nucleated cells in the body and display peptide antigens that are found within the cytoplasm of the cell

Question 19

What T cell mainly recognizes the MHC class I?

Answer 19

mainly recognized by CD8 cells because these are the cytotoxic cells that will kill cells infected in cytoplasm

Question 20

MHC Class II information

Answer 20

these are only found in antigen presenting cells..dendritic, macrophages and B cells

display antigens from microbes in vesicles in the infected cells

Question 21

What T cell mainly recognizes the MHC class II?

Answer 21

since displaying antigens from vesicles in the cell, these are mainly recognized by the CD4 cells since they will require helper cells

Question 22

MHC name in Humans

Answer 22

Human Leukocyte Antigens

Question 23

What chromosome is MHC on?

Answer 23

chromosome 6

Question 24

MHC Class I names

Answer 24

HLA-A, HLA-B, HLA-C

Question 25

MHC Class I chains

Answer 25

alpha chain with peptide binding cleft (a1,2,3), and beta-2 micro globulin for stability a3 binds cd8 cell

Question 26

transporter associated antigen processing for MHC class I

Answer 26

Proteasome breaks up into small peptides which go to ER where they are combined with MHC class I complex and then packaged and sent to membrane

Question 27

MHC Class II names

Answer 27

HLA-DP, HLA-DQ, HLA-DR

Question 28

MHC Class II chains

Answer 28

alpha and beta of equal size, both in membrane and both involved in binding the peptide b2 binds cd4 cell

Question 29

MHC Class II peptide association

Answer 29

phagocytosed an antigen, ER has MHC class II molecules with an invariant chain in the binding site, once antigen there the invariant chain leaves and the peptide can bind and the MHC II complex can go to membrane for recognition by CD4 cells

Question 30

co-dominant expression of MHC genes

Answer 30

both mom and dad genes are transcribed so means you have more possible MHC proteins to present

Question 31

polymorphic MHC genes

Answer 31

many different alleles in population so likely we are all different in MHC

Question 32

importance of slow off rate of peptides in MHC

Answer 32

gives plenty of time for T cells to recognize and proliferate

Question 33

celiac disease

Answer 33

gluten allergy that leads to fatty diarrhea, weight loss, and vitamin deficiencies autoimmune, some genetic linkage to HLA

Question 34

etiology of celiacs disease

Answer 34

villous atrophy intestines

Question 35

treatment of celiac disease

Answer 35

GF diet

Question 36

serological evaluation for celiacs

Answer 36

often have autoantibodies of EMA-IgA (antiendomysial) and tTG-IgA (transglutaminase antibody) and can test for these to do diagnosis also have antibody against gliadin (component of gluten) people also use endoscopy and biopsy

Question 37

type 1 diabetes

Answer 37

autoimmune destruction of beta cells that make insulin in pancreas some genetic linkage to HLA treat with exogenous insulin

Question 38

symptoms of type 1 diabetes

Answer 38

polydipsia (increased thirst) Polyuria (increased urine), weight loss hyperglycemia, diabetic ketoacidosis

Question 39

Auto-antibody testing for Type 1 diabetes

Answer 39

look for antibodies of anti glutamic acid decarboxylase, anti islet cell anti insulin

Question 40

celiac disease genetic links

Answer 40

HLA DQ2 and HLADQ8,

Question 41

type 1 diabetes genetic links

Answer 41

HLA DQ and HLA DR

Question 42

hyperacute organ rejection

Answer 42

immediate, due to pre-formed antibodies, like incompatibility of ABO blood types thrombosis occurs, organ dies not common anymore

Question 43

acute organ rejection

Answer 43

week to months due to developing B and T cells to foreign organ shows with vasculitis, treat with immunosupressants

Question 44

chronic organ rejection

Answer 44

years long, due to T and B cells leads to fibrosis or scarring and may need new transplant

Question 45

graft versus host disease

Answer 45

bone marrow transplant where the marrow makes new donor T cells that are sensitive against recipients MHC class...many organs effected

Question 46

Graft versus host disease presentation

Answer 46

rash, jaundice, diarrhea, hepatosplenomegaly