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Respiratory II Exam 1 > Lung Pathology VI > Flashcards

Lung Pathology VI Flashcards

1
Q

pulmonary hamartoma

A

popcorn calcification

has cartilage

benign, resectable

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2
Q

bronchioalveolar carcinoma

A

carcinoma in situ**

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3
Q

non-small-cell lung carcinomas

A

squamous cell
adenocarcinoma
large cell carcinomas

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4
Q

leading cause of cancer deaths

A

lung

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5
Q

cancer with smoking

A

lung, oral, pharyngeal, esophageal, pancreatic, cervical, renal, bladder

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6
Q

risk of lung cancer

A

determined by number of cigs smoked

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7
Q

4-aminobiphenyl 2 naphthylamine

A

bladder cancer from tobacco smoke

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8
Q

phenol

A

tumor promotion

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9
Q

polycyclic aromatic hydrocarbons

A

carcinogenesis in lungs and larynx

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10
Q

nitrosmaine

A

carcinogenesis

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11
Q

non-smoking female lung cancer

A

adenocarcinoma

peripheral location

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12
Q

squamous cell lung cancer

A

smoker - central location

-near hilum

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13
Q

EGFR or KRAS

A

in adenocarcinoma

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14
Q

RB and BCL2

A

in small cell carcinoma

strong association

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15
Q

p16 and P53

A

squamous cell carcinoma

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16
Q

chest pain, hemoptysis, weight loss

A

lung cancer

also pneumonia, abscess, lobar collapse, emphysema

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17
Q

pancoast tumor

A

apical lung tumor with pain in distribution of ulnar nerve and horner syndrome

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18
Q

horner syndrome

A

in pancoast tumor

enopthalmos, ptosis, miosis, and anhidrosis**

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19
Q

PTHrp

A

hypercalcemia

in squamous cell carcinoma

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20
Q

hypercalcemia with no metastasis

A

squamous cell carcinoma

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21
Q

lung carcinoma mets

A

to liver

and adrenal glands

22
Q

intercellular bridges

A

squamous cell carcinoma

23
Q

cuboidal/columnar glands

A

adenocarcinoma

24
Q

blue dots squished, large nucleus, no cytoplasm

A

small cell carcinoma

25
squamous cell carcinoma
central smokers hypercalcemia - PTHrp precursor - metaplasia, dysplasia, CIS
26
precursor lesions of squamous cell carcinoma
- goblet cell hyperplasia - basal cell hyperplasia - squamous metaplasia - squamous dysplasia - CIS - invasive squamous carcinoma
27
strap cells and squamous pearl
in squamous cell carcinomas orange staining cytologic diagnosis of lung cancer
28
adenocarcinoma
women and nonsmokers peripheral percursor - atypical adenomatous hyperplasia mucin TTF1 positive
29
TTF1 positive
supports diagnosis of adenocarcinoma
30
atypical adenomatous hyperplasia
precursor to adenocarcinoma
31
adenocarcinoma grading
more differentiated - lower grade
32
zellballen
in adenocarcinoma
33
less than 3cm growth along alveolar septa - no invasion
bronchioalveolar carcinoma**
34
microinvasive carcinoma
minimal invasive less than 3cm with less than 5mm of invasive component
35
aerogenous spread
bronchioloalveolar carcinoma in situ
36
lepidic growth along septa
bronchioalveolar carcinoma
37
large cell carcinoma
undifferentiated small percentage - neuroendocrine
38
carcinoid syndrome
diarrhea, flushing cyanosis MEN type I from diffuse idiopathic pulmonary neuroendocrine cell hyperplasia protrude into lumen of bronchus
39
small cell carcinoma
smokers central neuroendocrine very aggressive - chemoRx ADH - hyponatremia
40
hyponatremia
ADH - in small cell carcinoma
41
idiopathic endocrine cell hyperplasia
precursor lesion to small cell carcinoma
42
azzopardi effect
DNA stuck to blood vessel small cell carcinoma
43
staging of lung cancer
Tis = CIS T1 no mainstem bronchus T primary tumor N nodal metastasis M distal metastasis
44
small cell vs. non-small cell survival
non-small cell more survival small cell less survival
45
pleural neoplasm
likely metastasis - from lung or breast mesothelioma - asbestos
46
gold standard for pleural noeplasm
electromicroscopy
47
calretenin, mesothelin, WT-1
immunohistochem in pleural neoplasms
48
pleural solitary fibrous tumor
benign nodular lesion on surface of lung CD34 and keratin positive
49
pleural tumor ensheathing lung
mesothelioma
50
tightly packed and long microvilli
mesothelioma
51
short microvilli
adenocarcinoma

Respiratory II Exam 1 (11 decks)

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