Lung Pathology VI Flashcards

1
Q

pulmonary hamartoma

A

popcorn calcification

has cartilage

benign, resectable

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2
Q

bronchioalveolar carcinoma

A

carcinoma in situ**

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3
Q

non-small-cell lung carcinomas

A

squamous cell
adenocarcinoma
large cell carcinomas

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4
Q

leading cause of cancer deaths

A

lung

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5
Q

cancer with smoking

A

lung, oral, pharyngeal, esophageal, pancreatic, cervical, renal, bladder

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6
Q

risk of lung cancer

A

determined by number of cigs smoked

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7
Q

4-aminobiphenyl 2 naphthylamine

A

bladder cancer from tobacco smoke

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8
Q

phenol

A

tumor promotion

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9
Q

polycyclic aromatic hydrocarbons

A

carcinogenesis in lungs and larynx

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10
Q

nitrosmaine

A

carcinogenesis

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11
Q

non-smoking female lung cancer

A

adenocarcinoma

peripheral location

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12
Q

squamous cell lung cancer

A

smoker - central location

-near hilum

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13
Q

EGFR or KRAS

A

in adenocarcinoma

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14
Q

RB and BCL2

A

in small cell carcinoma

strong association

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15
Q

p16 and P53

A

squamous cell carcinoma

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16
Q

chest pain, hemoptysis, weight loss

A

lung cancer

also pneumonia, abscess, lobar collapse, emphysema

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17
Q

pancoast tumor

A

apical lung tumor with pain in distribution of ulnar nerve and horner syndrome

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18
Q

horner syndrome

A

in pancoast tumor

enopthalmos, ptosis, miosis, and anhidrosis**

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19
Q

PTHrp

A

hypercalcemia

in squamous cell carcinoma

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20
Q

hypercalcemia with no metastasis

A

squamous cell carcinoma

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21
Q

lung carcinoma mets

A

to liver

and adrenal glands

22
Q

intercellular bridges

A

squamous cell carcinoma

23
Q

cuboidal/columnar glands

A

adenocarcinoma

24
Q

blue dots squished, large nucleus, no cytoplasm

A

small cell carcinoma

25
Q

squamous cell carcinoma

A

central
smokers
hypercalcemia - PTHrp

precursor - metaplasia, dysplasia, CIS

26
Q

precursor lesions of squamous cell carcinoma

A
  • goblet cell hyperplasia
  • basal cell hyperplasia
  • squamous metaplasia
  • squamous dysplasia
  • CIS
  • invasive squamous carcinoma
27
Q

strap cells and squamous pearl

A

in squamous cell carcinomas

orange staining

cytologic diagnosis of lung cancer

28
Q

adenocarcinoma

A

women and nonsmokers
peripheral

percursor - atypical adenomatous hyperplasia

mucin
TTF1 positive

29
Q

TTF1 positive

A

supports diagnosis of adenocarcinoma

30
Q

atypical adenomatous hyperplasia

A

precursor to adenocarcinoma

31
Q

adenocarcinoma grading

A

more differentiated - lower grade

32
Q

zellballen

A

in adenocarcinoma

33
Q

less than 3cm growth along alveolar septa - no invasion

A

bronchioalveolar carcinoma**

34
Q

microinvasive carcinoma

A

minimal invasive

less than 3cm with less than 5mm of invasive component

35
Q

aerogenous spread

A

bronchioloalveolar carcinoma in situ

36
Q

lepidic growth along septa

A

bronchioalveolar carcinoma

37
Q

large cell carcinoma

A

undifferentiated

small percentage - neuroendocrine

38
Q

carcinoid syndrome

A

diarrhea, flushing cyanosis

MEN type I

from diffuse idiopathic pulmonary neuroendocrine cell hyperplasia

protrude into lumen of bronchus

39
Q

small cell carcinoma

A

smokers
central
neuroendocrine

very aggressive - chemoRx

ADH - hyponatremia

40
Q

hyponatremia

A

ADH - in small cell carcinoma

41
Q

idiopathic endocrine cell hyperplasia

A

precursor lesion to small cell carcinoma

42
Q

azzopardi effect

A

DNA stuck to blood vessel

small cell carcinoma

43
Q

staging of lung cancer

A

Tis = CIS
T1 no mainstem bronchus

T primary tumor
N nodal metastasis
M distal metastasis

44
Q

small cell vs. non-small cell survival

A

non-small cell more survival

small cell less survival

45
Q

pleural neoplasm

A

likely metastasis - from lung or breast

mesothelioma - asbestos

46
Q

gold standard for pleural noeplasm

A

electromicroscopy

47
Q

calretenin, mesothelin, WT-1

A

immunohistochem in pleural neoplasms

48
Q

pleural solitary fibrous tumor

A

benign nodular lesion on surface of lung

CD34 and keratin positive

49
Q

pleural tumor ensheathing lung

A

mesothelioma

50
Q

tightly packed and long microvilli

A

mesothelioma

51
Q

short microvilli

A

adenocarcinoma