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Respiratory II Exam 1 > Lung Pathology IV > Flashcards

Lung Pathology IV Flashcards

1
Q

desquamative interstitial pneumonia

A

lots of smokers macrophages in alveoli

NOT desquamative

> 50yo
Male

Tx - steroids and cessation of smoking

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2
Q

respiratory bronchiolitis associated interstitial lung disease

A

pigmented macrophages in bronchioles
-peribronchiolar fibrosis

30+ pack year history

Tx - stop smoking

**not as bad as macros in alveoli

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3
Q

pulmonary langerhans cell histiocytosis

A

eosinophilic granuloma

proliferating dendritic cells
-response to smoking

Tx - stop smoking

express CD1a, S-100, CD207

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4
Q

CD1a

A

seen in pulmonary langerhans cell histiocytosis

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5
Q

pulmonary alveolar proteinosis

A

cough and gelatinous chunky sputum

bilateral, patchy CXR

accumulation of acellular surfactatnt in intra-alveolar and bronchiolar spaces

autoimmune
secondary
congenital - fatal

Tx - pulmonary lavage and GM-CSF therapy or transplant

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6
Q

accumulation of acellular surfactant in intraalveolar bronchiolar spaces

A

pulmonary alveolar proteinosis

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7
Q

ABC3 gene mutation

A

pulmonary alveolar proteinosis

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8
Q

pulmonary embolism

A

SOB, chest pain, swollen leg

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9
Q

saddle embolus

A

massive PE - death

  • massive stress on right heart
  • right side HF

PEA

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10
Q

fever, chest pain, SOB, electromechanical dissociation, sudden death

A

pulmonary embolism

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11
Q

mismatch of V/Q

A

pulmonary embolus

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12
Q

gold standard for PE

A

angiography

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13
Q

other emboli

A

fat - has vacuoles
amniotic fluid - blue lines
air - iatrogenic
nitrogen - divers

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14
Q

amniotic fluid emboli

A

during delivery

  • can lead to DIC
  • many patients die
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15
Q

Fen/Phen

A

interstitial fibrosis of lung

led to pulmonary HTN

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16
Q

bush tea

A

backyard tea

can lead to pulmonary HTN

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17
Q

primary pulmonary arterial HTN

A

80% genetic

idiopathic

mostly females 20-40yo

autosomal dominant

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18
Q

BMPR2 mutation

A

idiopathic primary pulmonary arterial HTN

BMPR2 - inhibits proliferation of vascular smooth m

19
Q

secondary pulmonary HTN

A

normal rxn of arteries to increased pressure

medial hypertrophy

narrows arteries
-further increase P

lead to cor pulmonale

20
Q

atheromas

A

form with pulmonary HTN

21
Q

plexiform

A

severe long standing pulmonary HTN leads to oblitered lumen and revascularization**

22
Q

diffuse alveolar hemorrhage syndrome

A

causes

  • goodpastures
  • idiopathic pulmonary hemosiderosis
  • vasculitis

hemosiderin laden macrophages

23
Q

alpha3 chain of collagen IV

A

anti-BM membrane antibodies

-goodpasture syndrome

24
Q

proliferative rapidly progressive GN and necrotizing hemorrhagic interstitial pneumonitis

A

goodpasture

25
Q

goodpasture

A

M young smokers teens-20yo

pulmonary and renal symptoms

Tx - immunosuppression and plasmapharesis

26
Q

SOB, proteinuria, hematuria, elevated Cr, couging up blood, hemoptysis

A

goodpasture

27
Q

linear anti-BM deposits

A

lung and kidney

goodpasture

28
Q

idiopathic pulmonary hemosiderosis

A

rare, children

diffuse hemorrhage

hemosiderin deposition in macrophages and alveolar walls

Tx immunosuppression

bloody cough, weight loss, anemic

29
Q

cANCA

A

PR3

wegeners

30
Q

wegener granulomatosis

A

necrotizing granulomatous arteritis of lungs

wegeners

31
Q

upper resp lesions, vasculitis with granulomas, kidney problems

A

triad for wegeners

32
Q

pulmonary infectious disease

A

often viral

33
Q

splenectomy pts

A

lose ability to mount response to encapsulated pneumococcus**

34
Q

COPD pneumonia

A

haem influenza

gram - pleomorphic

35
Q

gram - pleomorphic

A

haem influenza

COPD pneumonia

36
Q

splenectomy/sickle cell pneumonia

A

streptococcus pneumonia

gram + diplococci

37
Q

post viral pneumonia

A

staph aureus

gram + cocci

38
Q

cystic fibrosis pneumonia

A

pseudomonas aeruginosa

gram - coccobacilli

39
Q

gram + diplococci

A

streptococcus pneumonia

splenectomy/sickle cell

40
Q

gram + cocci

A

staph aureus

post viral pneumonia

41
Q

legionella

A

macrophage response - not neutrophils

42
Q

debilitaed/malnourished pneumonia

A

klebsiella pneumoniae

gram - rod

43
Q

cold agglutinins

A

mycoplasma pneumoniae

44
Q

atypical pneumonias

A

chlamydia
viruses
mycoplasma
coxiella

Respiratory II Exam 1 (11 decks)

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