Lung Pathology III Flashcards
chronic diffuse interstitial lung disease
restrictive
end stage - honeycomb
CXR - reticulonodular and ground glass
problem at alveoli
pneumoconioses
inhale things that tear up your lung
idiopathic pulmonary fibrosis
usual interstitial pneumonia
aka cryptogenic fibrosing alveolitis
type II cell hyperplasia
interstitial around bronchi and subpleural**
TFG-beta1
in idiopathic pulmonary fibrosis
-reduce telomerase and inhibit caveolin (more collagen and fibrosis)
telomerase mutations in idiopathic pulmonary fibrosis
TERT and TERC
-LOF mutations
dyspnea, dry cough, hypoxemia, cyanosis, digital clubbing
idiopathic pulmonary fibrosis
repeated cycles of alveolitis
end in honeycomb lung
mean survival <3 years
nonspecific interstitial pneumonia
non-smoking females
-better prognosis than IPF
dyspnea and cough for several months
mild patchy or diffuse interstitial fibrosis
no honeycombing
bronchiolitis obliterans organizing pneumonia
BOOP
aka cryptogenic organizing pneumonia
organizing - all CT of same age and no interstitial fibrosis
Tx oral steroids > 6 months
fibrous deposits in distal bronchioles and alveolar spaces
CXR reticulonodular
caplan syndrome
rheumatoid arthritis and pneumoconiosis
work in mine > breathe in junk > scar lungs
soluble particle
acute problem
insoluble particle
chronic problem
bagasse
paper mill - plant fiber exposure
-people who make rum
farmers lung
mildy hay
anthracosis
coal dust - carbon
silicosis
silica
metal casting
sandblasting
stone cutting
asbestosis
asbestos
mining, milling, fabriction, insulation removal
coal workers pneumoconiosis
three types:
1 asymptomatic anthracosis - enter macrophage - doesn’t cause problems
2 simple CWP - coal macules and nodules and centrilobular emphysema
3 complicated CWP - progressive massive fibrosis
- pulmonary HTN and dysfunction
- to cor pulmonale
- SYMPTOMATIC - SOB
most prevalent chronic occupational disease in world
silicosis
-sandblasters, miners
slowly progressive
macrophage ingest silica - and killed - release TNF
worse - fresh cracked silica
polarizing crystals
silicosis
amphiboles
stiff brittle asbestos
-more harmful
chrysotile
serpentine asbestos
-less harmful
Dx of asbestosis
take lung and count asbestos in it
asbestos disease
pleural effusion pleural plaques lung cancer laryngeal carcinoma mesothelioma
beading and knobbed ends on with prussian blue stain
asbestos
-prussian blue - for iron
