Lung Cancer Flashcards
What is the leading cause of death from cancer worldwide in men and women?
1 - stroke
2 - lung cancer
3 - AIDs
4 - liver disease
2 - lung cancer
- 19% of new cancers
- 35,000 deaths/year in UK
- 3rd commonest cause of death in UK
What is the incidence of lung cancer?
1 - 40/year
2 - 400/year
3 - 4000/year
4 - 40,000/year
4 - 40,000/year
Does the risk of lung cancer increase with age?
- yes
Which of the following is NOT a risk factor for lung disease?
1 - Radiation
2 - Arsenic
3 - Coal tar
4 - Petroleum products
5 - Family History
6 - Diet
6 - Diet
What is the general latent period for lung cancer?
1 - 5-10 years
2 - 10-20 years
3 - 20-50 years
4 - 30-40 years
4 - 30-40 years
What is the main cause of lung disease, up to 90% of cases?
1 - family history
2 - diet
3 - smoking
4 - exposure of chemical at work
3 - smoking
- linear relationship with smoking and lung cancer
Can passive smoking increase the risk of lung cancer?
- yes
- but not as much as active smoking
What is the most common occupational risk factor for lung cancer?
1 - asbestos
2 - radiation
3 - smoke inhalation
4 - arsenic
1 - asbestos
Asbestos is the most common occupational cause of lung cancer. What is the latency period of asbestos exposure before developing lung cancer?
1 - 5-10 years
2 - 10-20 years
3 - 20-40 years
4 - 30-40 years
3 - 20-40 years
- 7 x increased risk of lung cancer in non-smoker
- 93 x increased risk of lung cancer in smoker + asbestos exposure
What % of lung cancers are due to genetic mutations?
1 - 0.8%
2 - 8%
3 - 18%
4 - 80%
2 - 8%
8% of lung cancers are due to genetic mutations. Which of the following are NOT genes commonly associated with lung cancer?
1 - BRCA1
2 - BRCA2
3 - RD51D
4 - p53
4 - p53
Are the following associated with small cell lung cancer or non-small cell lung cancer?
- Epidermal Growth Factor Receptor (EGFR)
- Programmed death ligand 1 and receptor (PD-L1)
- KRAS
- Anaplastic lymphoma kinase (ALK)
non-small cell lung cancer
A 52 year old man presents to his GP with a persistent cough. He works as a builder and has been fairly fit and well in the past. He has developed a cough recently. Which of the following would you NOT generally ask about his cough?
1 - onset
2 - duration
3 - dry/productive
4 - location of cough
5 -how much sputum?
4 - location of cough
A 52 year old man presents to his GP with a persistent cough. He works as a builder and has been fairly fit and well in the past. He has developed a cough recently. Which of the following would you NOT generally ask about in associated symptoms?
1 - shortness of breath
2 - mMRC score
3 - chest pain
4 - ankle oedema
5 - wheeze
4 - ankle oedema
A 52 year old man presents to his GP with a persistent cough. He works as a builder and has been fairly fit and well in the past. He has developed a cough recently. Which of the following would you NOT generally ask about in associated symptoms?
1 - shortness of breath
2 - mMRC score
3 - chest pain
4 - ankle oedema
5 - wheeze
4 - ankle oedema
A 52 year old man presents to his GP with a persistent cough. He works as a builder and has been fairly fit and well in the past. He has developed a cough recently. Which of the following is NOT typically a “Red Flag” symptoms you will ask about?
1 - haemoptysis
2 - weight loss
3 - fevers
4 - night sweats
5 - chest pain
5 - chest pain
A 52 year old man presents to his GP with a persistent cough. He works as a builder and has been fairly fit and well in the past. He has developed a cough recently. What risk factors will you NOT generally ask about?
1 - smoking
2 - genetic mutations
3 - asbestos exposure
4 - radiation
2 - genetic mutations
What is the most common presentation in a patient with lung cancer?
1 - Persistent cough (> 8 weeks)
2 - Worsening breathlessness
3 - Chest pain
4 - Haemoptysis
1 - Persistent cough (> 8 weeks)
Persistent cough (> 8 weeks) (80%)
Worsening breathlessness (60%)
Chest pain (50%)
Haemoptysis (30%)
Horners syndrome can be seen in patients with lung cancer. What is horners syndrome?
1 - problem with sympathetic tone on one side of the face
2 - problem with parasympathetic tone in whole face
3 - problem with sympathetic tone on whole face
4 - problem with parasympathetic tone on one side of the face
1 - problem with sympathetic tone on one side of the face
- tumour can compress sympathetic ganglia
Horners syndrome can be seen in patients with lung cancer and is a problem with sympathetic tone on one side of the face. Which of the following is NOT a symptom of horners syndrome?
1 - ptosis
2 - meiosis
3 - corneal arcus
4 - anhidrosis
3 - corneal arcus
In a cancer patient which of the following do we NOT commonly see when examining the patient?
1 - general appearance: cachexia, low BMI (normal 20-25)
2 - increased RR (> 20 bpm)
3 - tachycardia (> 100 bpm)
4 - Clubbing
5 - bradycardia (< 60 bpm)
6 - Hoarse voice
5 - bradycardia (< 60 bpm)
In a cancer patient which of the following do we NOT commonly see when examining the patient?
1 - horner’s syndrome (miosis, ptosis, anhidrosis and enophthalmos)
2 - pneumothorax
3 - lymphadenopathy (cervical or supraclavicular)
4 - tracheal deviation
5 - wheeze
2 - pneumothorax
A pleural effusion can occur in lung cancer. What is a pleural effusion?
1 - fluid filling space between lungs and chest wall
2 - fluid filled space between lungs and heart
3 - cardiomegaly
4 - carcinoma in pleural space
1 - fluid filling space between lungs and chest wall
In a patient with suspected lung cancer, which of the 2 of the following would be done immediately?
1 - CXR
2 - bronchoscopy
3 - Blood tests (FBC, U+Es, LFTs)
4 - PET scan
5 - lung function test
1 - CXR
3 - Blood tests (FBC, U+Es, LFTs)
In a patient with suspected lung cancer, we would perform a CXR and blood tests. Which of the following is NOT a standard investigation?
1 - lung drain and culture
2 - bronchoscopy
3 - PET scan
4 - lung function test
5 - CT scan
1 - lung drain and culture
When diagnosing lung cancer, is histology samples (tissue) or cytology (better?
- histology samples (tissue)
What is a nodule?
1 - abnormal growth of tissue
2 - cancerous growth of tissue
3 - benign growth of tissue
4 - pus filled cavity
1 - abnormal growth of tissue
- could be cancerous or benign
- always presume cancer until confirmed otherwise
When we want to quantify the functional impact cancer may have on the lungs, which scoring system do we use?
1 - Wellness score
2 - CURB65 score
3 - WHO Performance Status
4 - GOLD score
3 - WHO Performance Status
The WHO Performance Status is used to assess the impact cancer can have on patients function. The scoring has 5 levels, is 0 or 5 the worse score?
- 5
Brain, bone and an MRI of the thorax can often be performed in a patient with lung cancer. Why is this?
- investigate metastasis
Below is a list of benign tumours. Which is not a benign lung tumour?
1 - Hamartoma
2 - Arterio-venous malformations (AVMs)
3 - Carcinoid tumour
4 - Granuloma
5 - Adenocarcinoma
6 - Rheumatoid lung nodules
5 - Adenocarcinoma