Loops And Pathways Flashcards

1
Q

The subthalamic nucleus sends _________ to the GPi

A

Glutamate

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2
Q

The GPi sends _________ to the motor thalamus

A

GABA

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3
Q

The motor/premotor area of the cortex sends ________ to the subthalamic nucleus or putamen

A

Glutamate

It sends glutamate to putamen in GO pathway and NO GO

It sends glutamate to subthalamic nucleus in STOP

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4
Q

The putamen sends ______________ to the GPi or GPe depending on the pathway

A

GABA

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5
Q

The GPe sends __________ to the subthalamic nucleus

A

GABA

But when inhibited by the putamen it sends less GABA which disinhibits the GPi

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6
Q

Goal Directed behavior pathway

_________ prefrontal cortex -> ____________ -> GPi -> Thalamus

A

Lateral

Head of Caudate

Just remember: He’s goal directed with a good head on his shoulders :) Head of the caudate. Also it’s involved in the social loop because to be socially successful you have to have a good head on your shoulders. The head of the caudate is NOT in the emotional loop because being too emotional is the opposite of that.

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7
Q

Goal Directed behavior loop

Lateral prefrontal cortex -> head of caudate -> _________ -> ___________

A

GPi

Thalamus

Remember it takes discipline to accomplish your goals! So thats why the GPi is included (it inhibits unwanted behavior)

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8
Q

Which loop can have deficits of inattention, poor concentration, short term memory?

A

Goal directed behavior

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9
Q

Social Behavior loop

_____ prefrontal cortex -> __________ -> substantia nigra reticularis -> thalamus

Remember that being social makes you hapy so thats why this loop includes the substantia nigra (dopamine)

A

Ventral

Head of caudate

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10
Q

Social Behavior Loop

Ventral prefrontal cortex -> Head of caudate -> _____________ -> thalamus

A

Substantia Nigra Reticularis

social behavior gives you dopamine!

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11
Q

Deficits of what loop can lead to impulsivity, indifference, and violence?

A

Social Behavior Loop

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12
Q

Emotional Loop

______ prefrontal cortex -> ventral striatum -> thalamus

A

Medial

How I will remember: If you’re stuck in an emotional loop, you probably need to vent (ventral striatum)

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13
Q

Emotional Loop

Medial prefrontal cortex -> ________________ -> Thalamus

A

Ventral Striatum

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14
Q

Deficits of what loop lead to impaired reward seeking behavior/addiciton

A

Emotional Loop

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15
Q

A _______________ stroke causes depression and dulling of emotion

A

L basal ganglia,

Bc it damages the emotional loop

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16
Q

Occulomotor loop

Frontal/supplemental eye fields of cortex -> ___________ -> substantia nigra reticularis -> thalamus

A

Body of caudate

17
Q

Occulomotor loop

Frontal/supplemental eye field of cortex -> body of caudate -> ___________ -> thalamus

A

Substantia nigra reticularis

18
Q

Damage to Occulomotor loop leads to….

A

Impaired pro-saccades and anti-saccades

19
Q

Motor Loop

Motor/Premotor cortex -> ____________ -> Globus Pallidus -> Thalamus

A

Putamen

Men appreciate the motor loop so the putaMEN is involved!

20
Q

Motor Loop

Motor/premotor cortex -> Putamen -> _______________ -> thalamus

A

Globus Pallidus

21
Q

Stop pathway

  1. Motor cortex sends __________ to the subthalamic nucleus
  2. Subthalamic nucleus sends __________ to the ____________
  3. ___________ sends GABA to the motor thalamus
A

Glutamate

Glutamate

GPi

GPi

22
Q

Stop Pathway

  1. Motor cortex sends Glutamate to the __________
  2. ___________ sends glutamate to the GPi
  3. GPi sends __________ to the _____________
A

Subthalamic nucleus

Subthalamic nucleus

GABA

Motor Thalamus

23
Q

Go pathway

  1. Motor area of cortex sends __________ to the __________
  2. __________ sends GABA to the GPi
  3. GPi then sends ______________ to the motor thalamus
  4. Motor thalamus sends glutamate to the cortex
  5. Cortex sends _________ to LMNs
A

Glutamate

Putamen

Putamen

LESS GABA

Glutamate

24
Q

Go pathway

  1. Motor area of cortex sends glutamate to putamen
  2. Putamen sends ______________ to the ____________
  3. ___________ sends less GABA to the motor thalamus
  4. Motor thalamus sends _________ to the motor cortex
  5. Motor cortex sends Glutamate to the LMN
A

GABA

GPi

GPi

Glutamate

25
Q

No-go pathway

  1. Motor area of cortex sends ________ to the ___________
  2. __________ sends GABA to the GPe
  3. GPe sends ____________ to the subthalamic nucleus
  4. Subthalamic nucleus sends __________ to the GPi
  5. GPi sends GABA to motor thalamus
A

Glutamate , Putamen

Putamen

LESS GABA

Glutamate

26
Q

No Go pathway

  1. Motor area of cortex sends glutamate to putamen
  2. Putamen sends _____________ to __________
  3. ___________ sends less GABA to the subthalamic nucleus
  4. The subthalamic nucleus sends ___________ to the GPi
  5. GPi sends GABA to motor thalamus
A

GABA

GPe

GPe

Glutamate

27
Q

Cerebrocerebellar circuit:

Motor/pre motor cortex -> _________ -> lateral cerebellum -> ________ -> thalamus -> motor/pre motor cortex

A

Pontine nuclei

Dentate nuclei